Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4664060..4664870 Replicon chromosome
Accession NZ_CP103614
Organism Klebsiella pneumoniae strain 3571

Toxin (Protein)


Gene name KacT Uniprot ID A0A060VJ83
Locus tag M5T29_RS22740 Protein ID WP_004178461.1
Coordinates 4664060..4664593 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag M5T29_RS22745 Protein ID WP_002887278.1
Coordinates 4664604..4664870 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T29_RS22735 (M5T29_22735) 4662891..4664012 + 1122 WP_012737335.1 cupin domain-containing protein -
M5T29_RS22740 (M5T29_22740) 4664060..4664593 - 534 WP_004178461.1 type II toxin-antitoxin system toxin KacT Toxin
M5T29_RS22745 (M5T29_22745) 4664604..4664870 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
M5T29_RS22750 (M5T29_22750) 4664973..4666406 - 1434 WP_009484674.1 Cu(+)/Ag(+) sensor histidine kinase -
M5T29_RS22755 (M5T29_22755) 4666396..4667079 - 684 WP_004214143.1 copper response regulator transcription factor CusR -
M5T29_RS22760 (M5T29_22760) 4667252..4668637 + 1386 WP_048974497.1 efflux transporter outer membrane subunit -
M5T29_RS22765 (M5T29_22765) 4668655..4668999 + 345 WP_032433444.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19810.65 Da        Isoelectric Point: 5.2614

>T255835 WP_004178461.1 NZ_CP103614:c4664593-4664060 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT255835 WP_002887278.1 NZ_CP103614:c4664870-4664604 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060VJ83

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References