Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 205550..206289 Replicon chromosome
Accession NZ_CP103614
Organism Klebsiella pneumoniae strain 3571

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag M5T29_RS01015 Protein ID WP_021312536.1
Coordinates 205804..206289 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag M5T29_RS01010 Protein ID WP_003026799.1
Coordinates 205550..205816 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T29_RS00995 (M5T29_00995) 201054..203123 + 2070 WP_002922127.1 glycine--tRNA ligase subunit beta -
M5T29_RS01000 (M5T29_01000) 203419..204788 + 1370 WP_087661561.1 IS3 family transposase -
M5T29_RS01005 (M5T29_01005) 204989..205417 + 429 WP_004901287.1 GFA family protein -
M5T29_RS01010 (M5T29_01010) 205550..205816 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
M5T29_RS01015 (M5T29_01015) 205804..206289 + 486 WP_021312536.1 GNAT family N-acetyltransferase Toxin
M5T29_RS01020 (M5T29_01020) 206633..206785 + 153 WP_002922102.1 type I toxin-antitoxin system toxin HokA -
M5T29_RS01025 (M5T29_01025) 207087..208706 + 1620 WP_032432333.1 ATP-binding cassette domain-containing protein -
M5T29_RS01030 (M5T29_01030) 208805..209017 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
M5T29_RS01035 (M5T29_01035) 209270..209560 - 291 WP_002921931.1 HTH-type transcriptional regulator -
M5T29_RS01040 (M5T29_01040) 209806..211161 - 1356 WP_004901270.1 aromatic acid/H+ symport family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 204063..204788 725


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17608.39 Da        Isoelectric Point: 10.3370

>T255825 WP_021312536.1 NZ_CP103614:205804-206289 [Klebsiella pneumoniae]
VGRITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKKGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSQTQPRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT255825 WP_003026799.1 NZ_CP103614:205550-205816 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References