Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/ElaA-DUF1778
Location 97550..98289 Replicon plasmid pMB6956_1
Accession NZ_CP103612
Organism Enterobacter cloacae strain 3143

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag M5S62_RS24100 Protein ID WP_200928210.1
Coordinates 97804..98289 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag M5S62_RS24095 Protein ID WP_127851259.1
Coordinates 97550..97816 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S62_RS24075 (93465) 93465..93707 + 243 WP_251885365.1 hypothetical protein -
M5S62_RS24080 (94046) 94046..94813 + 768 WP_251885366.1 TraX family protein -
M5S62_RS24085 (94835) 94835..95131 - 297 WP_251885367.1 DUF2767 family protein -
M5S62_RS24090 (95914) 95914..96927 - 1014 WP_160890736.1 plasmid replication initiator RepA -
M5S62_RS24095 (97550) 97550..97816 + 267 WP_127851259.1 DUF1778 domain-containing protein Antitoxin
M5S62_RS24100 (97804) 97804..98289 + 486 WP_200928210.1 GNAT family N-acetyltransferase Toxin
M5S62_RS24105 (98497) 98497..98790 + 294 Protein_107 helix-turn-helix domain-containing protein -
M5S62_RS24110 (98911) 98911..99678 - 768 WP_251885368.1 DUF1883 domain-containing protein -
M5S62_RS24115 (99845) 99845..100459 + 615 WP_251885369.1 TIR domain-containing protein -
M5S62_RS24120 (100499) 100499..101206 - 708 WP_251885370.1 major royal jelly family protein -
M5S62_RS24125 (101233) 101233..101439 - 207 Protein_111 helix-turn-helix domain-containing protein -
M5S62_RS24130 (101821) 101821..102810 + 990 WP_251885371.1 tyrosine-type recombinase/integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..159348 159348


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(66-149)

Antitoxin

Vibrio phage ICP1, Orf50

(2-87)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17762.61 Da        Isoelectric Point: 10.4605

>T255824 WP_200928210.1 NZ_CP103612:97804-98289 [Enterobacter cloacae]
VGRVKAPEPLSSFHQLVEFVSGEVVLDDWLKQRGLKNQALGAARTFVVCKKNTKQVAGFYSLATGSVNHAEATGSLRRNM
PDPIPVIILARLAVDVSFRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEARSFYVHHGFKLSQTQNRTLFLKLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10065.45 Da        Isoelectric Point: 4.4733

>AT255824 WP_127851259.1 NZ_CP103612:97550-97816 [Enterobacter cloacae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVSNDAAIDKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References