Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4001281..4001941 Replicon chromosome
Accession NZ_CP103611
Organism Enterobacter cloacae strain 3143

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag M5S62_RS19035 Protein ID WP_129327560.1
Coordinates 4001281..4001694 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A5E1AG01
Locus tag M5S62_RS19040 Protein ID WP_013098615.1
Coordinates 4001675..4001941 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S62_RS19015 (M5S62_19015) 3997274..3999007 - 1734 WP_129327562.1 single-stranded-DNA-specific exonuclease RecJ -
M5S62_RS19020 (M5S62_19020) 3999013..3999726 - 714 WP_129327561.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M5S62_RS19025 (M5S62_19025) 3999755..4000651 - 897 WP_013098612.1 site-specific tyrosine recombinase XerD -
M5S62_RS19030 (M5S62_19030) 4000753..4001274 + 522 WP_013098613.1 flavodoxin FldB -
M5S62_RS19035 (M5S62_19035) 4001281..4001694 - 414 WP_129327560.1 protein YgfX Toxin
M5S62_RS19040 (M5S62_19040) 4001675..4001941 - 267 WP_013098615.1 FAD assembly factor SdhE Antitoxin
M5S62_RS19045 (M5S62_19045) 4002236..4003216 + 981 WP_023620448.1 tRNA-modifying protein YgfZ -
M5S62_RS19050 (M5S62_19050) 4003326..4003985 - 660 WP_003863433.1 hemolysin III family protein -
M5S62_RS19055 (M5S62_19055) 4004251..4004982 + 732 WP_259387762.1 MurR/RpiR family transcriptional regulator -
M5S62_RS19060 (M5S62_19060) 4005098..4006531 + 1434 WP_020687084.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16236.21 Da        Isoelectric Point: 10.9554

>T255821 WP_129327560.1 NZ_CP103611:c4001694-4001281 [Enterobacter cloacae]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLSSGMMLRLRQVGGGKCQHLWLAADSMDISEWRELRRMLLQQQPTQE

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10569.05 Da        Isoelectric Point: 5.1456

>AT255821 WP_013098615.1 NZ_CP103611:c4001941-4001675 [Enterobacter cloacae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDEDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5E1AG01

References