Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA(toxin)
Location 3318227..3320010 Replicon chromosome
Accession NZ_CP103611
Organism Enterobacter cloacae strain 3143

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag M5S62_RS15835 Protein ID WP_129327886.1
Coordinates 3318227..3319576 (+) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag M5S62_RS15840 Protein ID WP_029883072.1
Coordinates 3319573..3320010 (+) Length 146 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S62_RS15805 (M5S62_15805) 3313873..3313956 + 84 WP_000698460.1 small membrane protein YohP -
M5S62_RS15810 (M5S62_15810) 3314047..3314979 - 933 WP_013097946.1 tRNA dihydrouridine(16) synthase DusC -
M5S62_RS15815 (M5S62_15815) 3315147..3315545 + 399 WP_023619766.1 CidA/LrgA family protein -
M5S62_RS15820 (M5S62_15820) 3315542..3316237 + 696 WP_013097948.1 CidB/LrgB family autolysis modulator -
M5S62_RS15825 (M5S62_15825) 3316367..3317251 + 885 WP_023619765.1 cytidine deaminase -
M5S62_RS15830 (M5S62_15830) 3317379..3318092 + 714 WP_023619764.1 outer membrane permeability protein SanA -
M5S62_RS15835 (M5S62_15835) 3318227..3319576 + 1350 WP_129327886.1 HipA domain-containing protein Toxin
M5S62_RS15840 (M5S62_15840) 3319573..3320010 + 438 WP_029883072.1 helix-turn-helix transcriptional regulator Antitoxin
M5S62_RS15845 (M5S62_15845) 3320062..3321072 - 1011 WP_013097952.1 galactose/methyl galactoside ABC transporter permease MglC -
M5S62_RS15850 (M5S62_15850) 3321088..3322608 - 1521 WP_029883073.1 galactose/methyl galactoside ABC transporter ATP-binding protein MglA -
M5S62_RS15855 (M5S62_15855) 3322689..3323687 - 999 WP_014832691.1 galactose/glucose ABC transporter substrate-binding protein MglB -
M5S62_RS15860 (M5S62_15860) 3323984..3325006 - 1023 WP_020690130.1 HTH-type transcriptional regulator GalS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-405)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 450 a.a.        Molecular weight: 51164.80 Da        Isoelectric Point: 4.6006

>T255820 WP_129327886.1 NZ_CP103611:3318227-3319576 [Enterobacter cloacae]
METLTVQAYLNETWTDIALIKYPGSENNDWNTTQLDYLTEYAINFLDYDDFHAVSVNHPVSLFFDDQGQPGWLRFIDDII
PAGASRRYWINALDISELPVGQQNFLLLKFGTMSPVGNLRIKESVPEWNEFARTKTFTVADVIDRAADFLDYAQERGAAA
GGATGAGGEAPKLLLRCSETDAIWIDTWQNEPDNRDRYYLVKYPRGNRTEVDCNILRAEFHYYHELNAMGFSTIPVNTMR
LEEGSHYPSLWLPRFDIVRNEQDQLIRLGMESVYSLLQKAPGTLLDHEATLRALINKITSSHMVQQQGYQFDIPGFVTEW
VRRDLLNIIFGNSDNHGRNTAFVKAENHIMLSPVYDFAPMKADPEGIPRTLKWSLSCESGGDYNFNAIAQALAEWIPPTT
LLDALHETAIQLIDLPERLAARGVPDQIMEMPAIGFRYIPNKLFRWGLL

Download         Length: 1350 bp

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 16218.68 Da        Isoelectric Point: 10.6347

>AT255820 WP_029883072.1 NZ_CP103611:3319573-3320010 [Enterobacter cloacae]
MKISNKSESELLQTLARVRSVNEKRRHDEDEDPDKSSVVKRQRVSSGLTRISTLDRQAVLHAAIRDILLGKITQGEALKR
LRVEVLGMKQDEYAKLVSVSRKTLSDVENGRGNYSADIINKIFKPFGLQTGLVPISKSLIASLFT

Download         Length: 438 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References