Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1116927..1117547 Replicon chromosome
Accession NZ_CP103611
Organism Enterobacter cloacae strain 3143

Toxin (Protein)


Gene name Hha Uniprot ID A0A5E1A1U8
Locus tag M5S62_RS05245 Protein ID WP_013095889.1
Coordinates 1116927..1117145 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag M5S62_RS05250 Protein ID WP_008499288.1
Coordinates 1117173..1117547 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S62_RS05215 (M5S62_05215) 1112939..1113199 + 261 WP_006176933.1 type B 50S ribosomal protein L31 -
M5S62_RS05220 (M5S62_05220) 1113202..1113342 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
M5S62_RS05225 (M5S62_05225) 1113339..1114049 - 711 WP_045292921.1 GNAT family protein -
M5S62_RS05230 (M5S62_05230) 1114151..1115611 + 1461 WP_048970693.1 PLP-dependent aminotransferase family protein -
M5S62_RS05235 (M5S62_05235) 1115583..1116050 - 468 WP_013095887.1 YlaC family protein -
M5S62_RS05240 (M5S62_05240) 1116166..1116717 - 552 WP_013095888.1 maltose O-acetyltransferase -
M5S62_RS05245 (M5S62_05245) 1116927..1117145 - 219 WP_013095889.1 HHA domain-containing protein Toxin
M5S62_RS05250 (M5S62_05250) 1117173..1117547 - 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
M5S62_RS05255 (M5S62_05255) 1118060..1121206 - 3147 WP_013095890.1 multidrug efflux RND transporter permease subunit AcrB -
M5S62_RS05260 (M5S62_05260) 1121229..1122422 - 1194 WP_023620093.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8625.98 Da        Isoelectric Point: 8.9008

>T255815 WP_013095889.1 NZ_CP103611:c1117145-1116927 [Enterobacter cloacae]
MSDKPLTKTDYLMRLRRCQSIDTLERVIEKNKYELSDNELTVFYSAADHRLAELTMNKLYDKIPPSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT255815 WP_008499288.1 NZ_CP103611:c1117547-1117173 [Enterobacter cloacae]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5E1A1U8

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References