Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 508701..509217 Replicon chromosome
Accession NZ_CP103611
Organism Enterobacter cloacae strain 3143

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag M5S62_RS02435 Protein ID WP_058684032.1
Coordinates 508933..509217 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V3EXX3
Locus tag M5S62_RS02430 Protein ID WP_008501400.1
Coordinates 508701..508943 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S62_RS02415 (M5S62_02415) 504723..505463 + 741 WP_040020456.1 KDGP aldolase family protein -
M5S62_RS02420 (M5S62_02420) 505557..506693 + 1137 WP_129327021.1 lactonase family protein -
M5S62_RS02425 (M5S62_02425) 506713..508623 + 1911 WP_259387529.1 BglG family transcription antiterminator -
M5S62_RS02430 (M5S62_02430) 508701..508943 + 243 WP_008501400.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M5S62_RS02435 (M5S62_02435) 508933..509217 + 285 WP_058684032.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5S62_RS02440 (M5S62_02440) 509221..509685 - 465 WP_040020449.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
M5S62_RS02445 (M5S62_02445) 509822..511960 - 2139 WP_013095357.1 anaerobic ribonucleoside-triphosphate reductase -
M5S62_RS02450 (M5S62_02450) 512334..513977 - 1644 WP_058684031.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10930.81 Da        Isoelectric Point: 10.4251

>T255813 WP_058684032.1 NZ_CP103611:508933-509217 [Enterobacter cloacae]
MTYELEFDPRALKEWSKLGETVKKQFKKKLAGVLVNPRIESARLHNLPDCYKIKLRSQGYRLVYQVQDNVVTVVVIAIGK
REKSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8972.37 Da        Isoelectric Point: 5.0651

>AT255813 WP_008501400.1 NZ_CP103611:508701-508943 [Enterobacter cloacae]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTISDSEDALIQTVRERLANPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V3EXX3

References