Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 285887..286483 Replicon chromosome
Accession NZ_CP103611
Organism Enterobacter cloacae strain 3143

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag M5S62_RS01345 Protein ID WP_058684023.1
Coordinates 286181..286483 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag M5S62_RS01340 Protein ID WP_057072139.1
Coordinates 285887..286174 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S62_RS01335 (M5S62_01335) 284259..285890 + 1632 WP_013095027.1 Na/Pi cotransporter family protein -
M5S62_RS01340 (M5S62_01340) 285887..286174 - 288 WP_057072139.1 putative addiction module antidote protein Antitoxin
M5S62_RS01345 (M5S62_01345) 286181..286483 - 303 WP_058684023.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5S62_RS01350 (M5S62_01350) 286681..287550 + 870 WP_023621411.1 23S rRNA pseudouridine(2604) synthase RluF -
M5S62_RS01355 (M5S62_01355) 287618..288562 - 945 WP_013095031.1 ketopantoate/pantoate/pantothenate transporter PanS -
M5S62_RS01360 (M5S62_01360) 288655..290004 - 1350 WP_013095032.1 lysine-sensitive aspartokinase 3 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-93)

Antitoxin

Uncharacterized protein HI1420

(4-89)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11517.34 Da        Isoelectric Point: 9.9670

>T255812 WP_058684023.1 NZ_CP103611:c286483-286181 [Enterobacter cloacae]
MKEIVQTESFRRWEQNLKDRRARTIIASRLFRLANGLAGDIKPVGEGICELRIHFGPGYRIYFKDQGNYIIVLLCGGDKS
SQARDILMAKMLSNVSQWQE

Download         Length: 303 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10040.60 Da        Isoelectric Point: 5.7807

>AT255812 WP_057072139.1 NZ_CP103611:c286174-285887 [Enterobacter cloacae]
MHKLTPYDPAIALVDDEEIAVFMADALETGDSAYIAKALGVIARAKGMSAISQQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGLGLTIKPAGD

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References