Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 178943..179547 Replicon chromosome
Accession NZ_CP103611
Organism Enterobacter cloacae strain 3143

Toxin (Protein)


Gene name hicA Uniprot ID A0A421IJD5
Locus tag M5S62_RS00870 Protein ID WP_071843252.1
Coordinates 178943..179128 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A7Z1F6W0
Locus tag M5S62_RS00875 Protein ID WP_013094943.1
Coordinates 179143..179547 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S62_RS00855 (M5S62_00855) 175374..176912 + 1539 WP_020686520.1 aldehyde dehydrogenase family protein -
M5S62_RS00860 (M5S62_00860) 176909..177874 - 966 WP_061771396.1 LysR family transcriptional regulator -
M5S62_RS00865 (M5S62_00865) 177992..178732 + 741 WP_013094942.1 MipA/OmpV family protein -
M5S62_RS00870 (M5S62_00870) 178943..179128 + 186 WP_071843252.1 type II toxin-antitoxin system HicA family toxin Toxin
M5S62_RS00875 (M5S62_00875) 179143..179547 + 405 WP_013094943.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
M5S62_RS00880 (M5S62_00880) 179601..181556 - 1956 WP_259387515.1 glycoside hydrolase family 127 protein -
M5S62_RS00885 (M5S62_00885) 181567..182967 - 1401 WP_129327141.1 MFS transporter -
M5S62_RS00890 (M5S62_00890) 183192..184010 + 819 WP_020686525.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6859.08 Da        Isoelectric Point: 11.7891

>T255811 WP_071843252.1 NZ_CP103611:178943-179128 [Enterobacter cloacae]
VKSADVITVLVRHGWKCVRTKGSHHQFRHPVHAGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Download         Length: 186 bp

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14915.74 Da        Isoelectric Point: 4.3036

>AT255811 WP_013094943.1 NZ_CP103611:179143-179547 [Enterobacter cloacae]
MFYPAYIHSDPDGSASGFFPDVPGCFFAGNSLDDAFQDARDALTAHFEALFEMDEELPLPGNVEAHLEATPGDFIGGQWL
LVDINMKQFDGKAERINITLPRRLLVKIDSFVNEHPQFSNRSAFLAEAARRVLP

Download         Length: 405 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A421IJD5

Antitoxin

Source ID Structure
AlphaFold DB A0A7Z1F6W0

References