Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1632891..1633559 Replicon chromosome
Accession NC_015875
Organism Streptococcus pseudopneumoniae IS7493

Toxin (Protein)


Gene name hicA Uniprot ID G0ICE6
Locus tag SPPN_RS08345 Protein ID WP_001132281.1
Coordinates 1633380..1633559 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag SPPN_RS08340 Protein ID WP_000961810.1
Coordinates 1632891..1633343 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SPPN_RS08315 1628781..1629524 - 744 WP_001188219.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
SPPN_RS08320 1629526..1630476 - 951 WP_000451162.1 50S ribosomal protein L11 methyltransferase -
SPPN_RS08325 1630614..1631042 - 429 WP_000418168.1 NUDIX hydrolase -
SPPN_RS08330 1631023..1632111 - 1089 WP_000719722.1 M50 family metallopeptidase -
SPPN_RS08335 1632130..1632600 - 471 WP_000257101.1 DUF3013 family protein -
SPPN_RS08340 1632891..1633343 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
SPPN_RS08345 1633380..1633559 - 180 WP_001132281.1 type II toxin-antitoxin system HicA family toxin Toxin
SPPN_RS08350 1633696..1633884 - 189 WP_001862821.1 hypothetical protein -
SPPN_RS08355 1634039..1634254 - 216 WP_075329187.1 hypothetical protein -
SPPN_RS08360 1634542..1635813 + 1272 WP_001113218.1 replication-associated recombination protein A -
SPPN_RS08370 1636359..1637678 - 1320 WP_000502536.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6695.92 Da        Isoelectric Point: 11.0174

>T25580 WP_001132281.1 NC_015875:c1633559-1633380 [Streptococcus pseudopneumoniae IS7493]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKIEKQGERPITILHGELNKYTERGIRKQAGL

Download         Length: 180 bp

>T25580 NC_015875:c1633559-1633380 [Streptococcus pseudopneumoniae IS7493]
ATGCCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATCGAGAAGCAAGGGGAAAGACCTATCACAATCCTTCATGGTGAGCTGAATAAGTACACTGAAAGAGGGATAA
GAAAGCAAGCTGGGTTGTAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT25580 WP_000961810.1 NC_015875:c1633343-1632891 [Streptococcus pseudopneumoniae IS7493]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT25580 NC_015875:c1633343-1632891 [Streptococcus pseudopneumoniae IS7493]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0ICE6

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References