Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1421834..1422452 Replicon chromosome
Accession NZ_CP103609
Organism Escherichia coli strain 4314

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag M5S83_RS06930 Protein ID WP_001291435.1
Coordinates 1421834..1422052 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag M5S83_RS06935 Protein ID WP_000344800.1
Coordinates 1422078..1422452 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S83_RS06895 (1417124) 1417124..1417696 + 573 WP_000779826.1 YbaY family lipoprotein -
M5S83_RS06900 (1417727) 1417727..1418038 - 312 WP_000409911.1 MGMT family protein -
M5S83_RS06910 (1418417) 1418417..1418770 + 354 WP_000878140.1 DUF1428 domain-containing protein -
M5S83_RS06915 (1418812) 1418812..1420362 - 1551 WP_024166621.1 cyclic-guanylate-specific phosphodiesterase PdeB -
M5S83_RS06920 (1420526) 1420526..1420996 - 471 WP_000136192.1 YlaC family protein -
M5S83_RS06925 (1421112) 1421112..1421663 - 552 WP_000102556.1 maltose O-acetyltransferase -
M5S83_RS06930 (1421834) 1421834..1422052 - 219 WP_001291435.1 HHA domain-containing protein Toxin
M5S83_RS06935 (1422078) 1422078..1422452 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
M5S83_RS06940 (1422998) 1422998..1426147 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
M5S83_RS06945 (1426170) 1426170..1427363 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T255796 WP_001291435.1 NZ_CP103609:c1422052-1421834 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT255796 WP_000344800.1 NZ_CP103609:c1422452-1422078 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References