Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 672451..673046 Replicon chromosome
Accession NZ_CP103609
Organism Escherichia coli strain 4314

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag M5S83_RS03270 Protein ID WP_000239579.1
Coordinates 672696..673046 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag M5S83_RS03265 Protein ID WP_001223208.1
Coordinates 672451..672702 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S83_RS03255 (668115) 668115..671894 + 3780 WP_000060921.1 autotransporter assembly complex protein TamB -
M5S83_RS03260 (671897) 671897..672238 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
M5S83_RS03265 (672451) 672451..672702 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
M5S83_RS03270 (672696) 672696..673046 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
M5S83_RS03275 (673126) 673126..673656 - 531 WP_000055070.1 inorganic diphosphatase -
M5S83_RS03280 (673966) 673966..674922 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
M5S83_RS03285 (675062) 675062..676564 + 1503 WP_000205800.1 sugar ABC transporter ATP-binding protein -
M5S83_RS03290 (676578) 676578..677600 + 1023 WP_001296689.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T255793 WP_000239579.1 NZ_CP103609:672696-673046 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT255793 WP_001223208.1 NZ_CP103609:672451-672702 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References