Detailed information of TA system TA025579

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1573716..1574343
• Replicon: chromosome
• Accession: NC_015875
• Organism: Streptococcus pseudopneumoniae IS7493

Toxin (Protein)

• Gene name: parE
• Uniprot ID: G0IC07
• Locus tag: SPPN_RS08060
• Protein ID: WP_000384969.1
• Coordinates: 1573716..1574066 (-)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: G0IC08
• Locus tag: SPPN_RS08065
• Protein ID: WP_000150674.1
• Coordinates: 1574056..1574343 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SPPN_RS08045	1569835..1570431	-	597	WP_000966760.1	recombination mediator RecR	-
SPPN_RS08050	1570442..1572499	-	2058	WP_080564682.1	penicillin-binding protein 2B	-
SPPN_RS08055	1572803..1573654	+	852	WP_000360356.1	MurR/RpiR family transcriptional regulator	-
SPPN_RS08060	1573716..1574066	-	351	WP_000384969.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SPPN_RS08065	1574056..1574343	-	288	WP_000150674.1	hypothetical protein	Antitoxin
SPPN_RS08070	1574440..1575324	-	885	WP_000150277.1	ROK family protein	-
SPPN_RS08075	1575342..1576259	-	918	WP_001281495.1	dihydrodipicolinate synthase family protein	-
SPPN_RS08080	1576429..1577073	-	645	WP_000057493.1	YesL family protein	-
SPPN_RS08090	1577357..1577701	-	345	WP_014017319.1	hypothetical protein	-
SPPN_RS08095	1578028..1578480	-	453	WP_000575441.1	YhcH/YjgK/YiaL family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-104)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 13846.96 Da
• Isoelectric Point: 9.8271

>T25579 WP_000384969.1 NC_015875:c1574066-1573716 [Streptococcus pseudopneumoniae IS7493]
MDYKRYRILYSPRVIDSLDKIYQYIAEEIGSVEAARRKVANIRKDINRLEIFPQAGFDADEKFGKKLDPRYQTRGWTLSK
DYIVLYTIVEDTVRLAYLLPSKSDYMKLFKTKSRYD

Nucleotide

• Length: 351 bp

>T25579 NC_015875:c1574066-1573716 [Streptococcus pseudopneumoniae IS7493]
ATGGATTATAAAAGATATAGGATTTTGTATTCTCCTAGAGTGATTGATAGTCTGGATAAAATATATCAGTATATAGCGGA
GGAAATCGGTTCTGTAGAGGCTGCGAGACGAAAAGTAGCCAATATTAGAAAAGATATTAATCGGCTAGAAATTTTCCCCC
AAGCTGGATTTGATGCTGATGAAAAATTTGGTAAGAAATTAGACCCTCGCTACCAAACGCGAGGATGGACCTTGAGTAAG
GATTACATTGTATTGTATACAATTGTTGAGGATACCGTCAGACTTGCTTATTTACTCCCTTCAAAAAGTGATTACATGAA
ATTATTCAAGACTAAGTCAAGATATGACTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10848.24 Da
• Isoelectric Point: 4.2298

>AT25579 WP_000150674.1 NC_015875:c1574343-1574056 [Streptococcus pseudopneumoniae IS7493]
MTIANSSKIVTFQANRELVNDAMEVLKEKNLSLSSALRLFLKNVAVTNEVDLLSEEELEKEYLFRQLQAEVQESYAKIES
GNYLTDEDVVTRYGL

Nucleotide

• Length: 288 bp

>AT25579 NC_015875:c1574343-1574056 [Streptococcus pseudopneumoniae IS7493]
ATGACTATAGCGAATTCAAGTAAGATTGTGACCTTCCAAGCTAATAGAGAATTAGTAAATGATGCCATGGAAGTGTTAAA
AGAAAAAAATCTCTCTCTTTCATCAGCACTCAGATTATTTTTAAAGAATGTTGCCGTAACAAATGAAGTAGATTTACTGA
GTGAAGAGGAATTAGAGAAGGAGTATTTGTTTAGACAATTACAAGCAGAAGTTCAAGAAAGTTATGCCAAGATTGAGTCT
GGAAATTACTTGACAGATGAGGATGTCGTGACACGCTATGGATTATAA

Structures

Toxin

• AlphaFold DB: G0IC07

Antitoxin

• AlphaFold DB: G0IC08