Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4832426..4834107 Replicon chromosome
Accession NZ_CP103605
Organism Klebsiella pneumoniae strain 4386

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag M5S85_RS23415 Protein ID WP_002885155.1
Coordinates 4832426..4833343 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag M5S85_RS23420 Protein ID WP_004177809.1
Coordinates 4833349..4834107 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S85_RS23395 (4827732) 4827732..4829252 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
M5S85_RS23400 (4829249) 4829249..4830247 + 999 WP_002885172.1 ribose ABC transporter permease -
M5S85_RS23405 (4830278) 4830278..4831219 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
M5S85_RS23410 (4831294) 4831294..4832301 + 1008 WP_004177805.1 carbohydrate kinase family protein -
M5S85_RS23415 (4832426) 4832426..4833343 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
M5S85_RS23420 (4833349) 4833349..4834107 - 759 WP_004177809.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
M5S85_RS23425 (4834193) 4834193..4834921 - 729 WP_023159071.1 response regulator transcription factor -
M5S85_RS23430 (4835194) 4835194..4837341 + 2148 WP_012737173.1 formate dehydrogenase H subunit alpha, selenocysteine-containing -
M5S85_RS23435 (4837571) 4837571..4838257 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T255787 WP_002885155.1 NZ_CP103605:c4833343-4832426 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT255787 WP_004177809.1 NZ_CP103605:c4834107-4833349 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A6TH05

References