Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4671251..4671767 Replicon chromosome
Accession NZ_CP103605
Organism Klebsiella pneumoniae strain 4386

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag M5S85_RS22615 Protein ID WP_002886902.1
Coordinates 4671251..4671535 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag M5S85_RS22620 Protein ID WP_002886901.1
Coordinates 4671525..4671767 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S85_RS22590 (4666668) 4666668..4666931 - 264 WP_228985702.1 PTS sugar transporter subunit IIB -
M5S85_RS22595 (4667061) 4667061..4667234 + 174 WP_032410138.1 hypothetical protein -
M5S85_RS22600 (4667237) 4667237..4667980 + 744 WP_021441079.1 MurR/RpiR family transcriptional regulator -
M5S85_RS22605 (4668337) 4668337..4670475 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
M5S85_RS22610 (4670783) 4670783..4671247 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
M5S85_RS22615 (4671251) 4671251..4671535 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5S85_RS22620 (4671525) 4671525..4671767 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M5S85_RS22625 (4671845) 4671845..4673755 - 1911 WP_004152270.1 PRD domain-containing protein -
M5S85_RS22630 (4673778) 4673778..4674932 - 1155 WP_002886900.1 lactonase family protein -
M5S85_RS22635 (4674999) 4674999..4675739 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T255786 WP_002886902.1 NZ_CP103605:c4671535-4671251 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT255786 WP_002886901.1 NZ_CP103605:c4671767-4671525 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References