Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2606934..2608522 Replicon chromosome
Accession NZ_CP103605
Organism Klebsiella pneumoniae strain 4386

Toxin (Protein)


Gene name hipA Uniprot ID A6T928
Locus tag M5S85_RS12720 Protein ID WP_004176197.1
Coordinates 2606934..2608256 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag M5S85_RS12725 Protein ID WP_032417111.1
Coordinates 2608256..2608522 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S85_RS12705 (2601990) 2601990..2604491 + 2502 WP_016831617.1 fimbria/pilus outer membrane usher protein -
M5S85_RS12710 (2604479) 2604479..2605483 + 1005 WP_004176196.1 fimbrial protein -
M5S85_RS12715 (2605625) 2605625..2606917 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
M5S85_RS12720 (2606934) 2606934..2608256 - 1323 WP_004176197.1 type II toxin-antitoxin system HipA family toxin Toxin
M5S85_RS12725 (2608256) 2608256..2608522 - 267 WP_032417111.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
M5S85_RS12730 (2608787) 2608787..2609113 - 327 WP_002904788.1 hydroxyisourate hydrolase -
M5S85_RS12735 (2609110) 2609110..2609610 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
M5S85_RS12740 (2609588) 2609588..2610967 - 1380 WP_021440115.1 nucleobase:cation symporter-2 family protein -
M5S85_RS12745 (2611313) 2611313..2612464 + 1152 Protein_2493 FAD-dependent urate hydroxylase HpxO -
M5S85_RS12750 (2612448) 2612448..2613371 - 924 WP_259429784.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49111.41 Da        Isoelectric Point: 7.5357

>T255783 WP_004176197.1 NZ_CP103605:c2608256-2606934 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9926.32 Da        Isoelectric Point: 8.5912

>AT255783 WP_032417111.1 NZ_CP103605:c2608522-2608256 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETASAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6T928

Antitoxin

Source ID Structure

References