Detailed information of TA system TA025578

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1130551..1131049
• Replicon: chromosome
• Accession: NC_015875
• Organism: Streptococcus pseudopneumoniae IS7493

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: SPPN_RS05850
• Protein ID: WP_014017264.1
• Coordinates: 1130551..1130805 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: F9HDX8
• Locus tag: SPPN_RS05855
• Protein ID: WP_000208079.1
• Coordinates: 1130807..1131049 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SPPN_RS05840	1127544..1128494	-	951	WP_000658131.1	Abi family protein	-
SPPN_RS05845	1128604..1130475	-	1872	WP_000963214.1	Eco57I restriction-modification methylase domain-containing protein	-
SPPN_RS05850	1130551..1130805	-	255	WP_014017264.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SPPN_RS05855	1130807..1131049	-	243	WP_000208079.1	hypothetical protein	Antitoxin
SPPN_RS05860	1131140..1131949	-	810	WP_001289495.1	MBL fold metallo-hydrolase	-
SPPN_RS05865	1131951..1133300	-	1350	WP_000886221.1	cell wall metabolism sensor histidine kinase VicK	-
SPPN_RS05870	1133293..1133997	-	705	WP_000722069.1	response regulator transcription factor	-
SPPN_RS05875	1134053..1135228	-	1176	WP_000886139.1	A/G-specific adenine glycosylase	-
SPPN_RS13190	1135274..1135444	-	171	WP_158083587.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-84)

Antitoxin

• Protein of unknown function DUF6290 (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10045.75 Da
• Isoelectric Point: 10.4376

>T25578 WP_014017264.1 NC_015875:c1130805-1130551 [Streptococcus pseudopneumoniae IS7493]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQSNVLEDPRRHGKALVGNRVGQWCYRIGNYRVIVQIVDDELVIATLEVGHR
RDIY

Nucleotide

• Length: 255 bp

>T25578 NC_015875:c1130805-1130551 [Streptococcus pseudopneumoniae IS7493]
TTGTATAAATTAGTTCCGACAAGACGATTCATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAATCCAATGTTTTGGAAGACCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGTGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTCATTGCTACTCTAGAAGTTGGTCATAGG
AGAGATATTTATTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9206.40 Da
• Isoelectric Point: 3.9338

>AT25578 WP_000208079.1 NC_015875:c1131049-1130807 [Streptococcus pseudopneumoniae IS7493]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLEDE

Nucleotide

• Length: 243 bp

>AT25578 NC_015875:c1131049-1130807 [Streptococcus pseudopneumoniae IS7493]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCTCT
GTCGGAACTTATCCGCACCAAAACTCTTGAAGCTCTAGAAGACGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGGAGGATGAA
TAA

Structures

Antitoxin

• AlphaFold DB: F9HDX8