Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 843662..844319 Replicon chromosome
Accession NZ_CP103605
Organism Klebsiella pneumoniae strain 4386

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag M5S85_RS04210 Protein ID WP_002916310.1
Coordinates 843909..844319 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag M5S85_RS04205 Protein ID WP_002916312.1
Coordinates 843662..843928 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S85_RS04180 (838818) 838818..840251 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
M5S85_RS04185 (840370) 840370..841098 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
M5S85_RS04190 (841148) 841148..841459 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
M5S85_RS04195 (841623) 841623..842282 + 660 WP_002916317.1 hemolysin III family protein -
M5S85_RS04200 (842433) 842433..843416 - 984 WP_004185555.1 tRNA-modifying protein YgfZ -
M5S85_RS04205 (843662) 843662..843928 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
M5S85_RS04210 (843909) 843909..844319 + 411 WP_002916310.1 protein YgfX Toxin
M5S85_RS04215 (844326) 844326..844847 - 522 WP_004144730.1 flavodoxin FldB -
M5S85_RS04220 (844948) 844948..845844 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
M5S85_RS04225 (845867) 845867..846580 + 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M5S85_RS04230 (846586) 846586..848319 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T255778 WP_002916310.1 NZ_CP103605:843909-844319 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT255778 WP_002916312.1 NZ_CP103605:843662-843928 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References