Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 50967..51514 Replicon plasmid pMB7536_1
Accession NZ_CP103597
Organism Escherichia coli strain 4848

Toxin (Protein)


Gene name parE Uniprot ID G7QEJ9
Locus tag M5T19_RS23185 Protein ID WP_001384452.1
Coordinates 50967..51245 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag M5T19_RS23190 Protein ID WP_000079941.1
Coordinates 51245..51514 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T19_RS23155 (46397) 46397..46657 + 261 WP_000343091.1 hypothetical protein -
M5T19_RS23160 (46654) 46654..47244 + 591 WP_001518980.1 hypothetical protein -
M5T19_RS23165 (47306) 47306..47521 - 216 Protein_43 DUF6404 family protein -
M5T19_RS23170 (47650) 47650..47985 + 336 WP_001080729.1 colicin 1A immunity protein -
M5T19_RS23175 (48007) 48007..49887 - 1881 WP_001283335.1 colicin Ia central receptor-binding domain-containing protein -
M5T19_RS23180 (50073) 50073..50921 - 849 WP_001057989.1 3'-5' exonuclease -
M5T19_RS23185 (50967) 50967..51245 - 279 WP_001384452.1 type II toxin-antitoxin system toxin YacB Toxin
M5T19_RS23190 (51245) 51245..51514 - 270 WP_000079941.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
M5T19_RS23195 (52158) 52158..55124 - 2967 WP_001138014.1 Tn3-like element TnAs1 family transposase -
M5T19_RS23200 (55128) 55128..55688 - 561 WP_001161490.1 recombinase family protein -
M5T19_RS23205 (55864) 55864..56214 - 351 WP_000454193.1 DUF3330 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid dfrA5 / blaTEM-1B / sitABCD iroB / iroC / iroD / iroE / iroN / iutA / iucD / iucC / iucB / iucA 1..133650 133650


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10762.38 Da        Isoelectric Point: 8.4615

>T255772 WP_001384452.1 NZ_CP103597:c51245-50967 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10252.58 Da        Isoelectric Point: 7.2057

>AT255772 WP_000079941.1 NZ_CP103597:c51514-51245 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CL36

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References