Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4145854..4146449 Replicon chromosome
Accession NZ_CP103596
Organism Escherichia coli strain 4848

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag M5T19_RS20170 Protein ID WP_000239579.1
Coordinates 4145854..4146204 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag M5T19_RS20175 Protein ID WP_001223208.1
Coordinates 4146198..4146449 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T19_RS20150 (4141130) 4141130..4142152 - 1023 WP_024198507.1 ABC transporter permease -
M5T19_RS20155 (4142166) 4142166..4143668 - 1503 WP_000205791.1 sugar ABC transporter ATP-binding protein -
M5T19_RS20160 (4143978) 4143978..4144934 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
M5T19_RS20165 (4145244) 4145244..4145774 + 531 WP_000055072.1 inorganic diphosphatase -
M5T19_RS20170 (4145854) 4145854..4146204 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
M5T19_RS20175 (4146198) 4146198..4146449 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
M5T19_RS20180 (4146662) 4146662..4147003 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
M5T19_RS20185 (4147006) 4147006..4150785 - 3780 WP_000060921.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T255770 WP_000239579.1 NZ_CP103596:c4146204-4145854 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT255770 WP_001223208.1 NZ_CP103596:c4146449-4146198 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References