Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 898910..899533 | Replicon | chromosome |
| Accession | NC_015875 | ||
| Organism | Streptococcus pseudopneumoniae IS7493 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | G0I8P0 |
| Locus tag | SPPN_RS04640 | Protein ID | WP_001131503.1 |
| Coordinates | 898910..899098 (+) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | G0I8P1 |
| Locus tag | SPPN_RS04645 | Protein ID | WP_000921490.1 |
| Coordinates | 899156..899533 (+) | Length | 126 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SPPN_RS04585 | 894046..894216 | + | 171 | WP_000512112.1 | twin-arginine translocase TatA/TatE family subunit | - |
| SPPN_RS04590 | 894352..894711 | - | 360 | WP_000221462.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| SPPN_RS04595 | 894701..894985 | - | 285 | WP_000213592.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| SPPN_RS04600 | 895163..895447 | - | 285 | WP_162467680.1 | type B 50S ribosomal protein L31 | - |
| SPPN_RS04605 | 895501..896436 | - | 936 | WP_000401749.1 | bifunctional oligoribonuclease/PAP phosphatase NrnA | - |
| SPPN_RS04610 | 896540..896983 | + | 444 | WP_000241951.1 | flavodoxin | - |
| SPPN_RS04615 | 897099..897365 | + | 267 | WP_000362492.1 | chorismate mutase | - |
| SPPN_RS04620 | 897362..897736 | + | 375 | WP_000712082.1 | fluoride efflux transporter CrcB | - |
| SPPN_RS04625 | 897730..898059 | + | 330 | WP_000237406.1 | fluoride efflux transporter CrcB | - |
| SPPN_RS04630 | 898178..898525 | + | 348 | WP_001068669.1 | 50S ribosomal protein L19 | - |
| SPPN_RS04640 | 898910..899098 | + | 189 | WP_001131503.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| SPPN_RS04645 | 899156..899533 | + | 378 | WP_000921490.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| SPPN_RS04650 | 899623..899784 | + | 162 | WP_000077979.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| SPPN_RS04655 | 899830..900144 | + | 315 | WP_000263130.1 | nucleotidyltransferase domain-containing protein | - |
| SPPN_RS04660 | 900125..900499 | + | 375 | WP_001257560.1 | DUF86 domain-containing protein | - |
| SPPN_RS04665 | 900626..900835 | + | 210 | Protein_926 | site-specific recombinase | - |
| SPPN_RS12770 | 900850..900957 | - | 108 | Protein_927 | IS5/IS1182 family transposase | - |
| SPPN_RS11965 | 901060..901758 | - | 699 | Protein_928 | transposase | - |
| SPPN_RS04680 | 902108..902914 | - | 807 | WP_000023513.1 | sugar-phosphatase | - |
| SPPN_RS04685 | 902927..904231 | - | 1305 | WP_001003511.1 | HD domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 901057..901344 | 287 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7038.21 Da Isoelectric Point: 9.8162
>T25577 WP_001131503.1 NC_015875:898910-899098 [Streptococcus pseudopneumoniae IS7493]
MPLTGKEMVKLALENGWVEVRQRGSHHHFKKEGFSYLVTIPVHGNEDLGKGLERKILKDLGL
MPLTGKEMVKLALENGWVEVRQRGSHHHFKKEGFSYLVTIPVHGNEDLGKGLERKILKDLGL
Download Length: 189 bp
>T25577 NC_015875:898910-899098 [Streptococcus pseudopneumoniae IS7493]
ATGCCACTTACAGGTAAAGAAATGGTGAAACTAGCTCTTGAGAATGGATGGGTTGAAGTTCGTCAAAGAGGAAGTCATCA
TCATTTTAAGAAAGAGGGTTTTTCTTATCTTGTCACGATTCCAGTTCATGGAAATGAAGATTTGGGAAAGGGATTGGAGA
GAAAGATTCTCAAAGATTTAGGATTGTAA
ATGCCACTTACAGGTAAAGAAATGGTGAAACTAGCTCTTGAGAATGGATGGGTTGAAGTTCGTCAAAGAGGAAGTCATCA
TCATTTTAAGAAAGAGGGTTTTTCTTATCTTGTCACGATTCCAGTTCATGGAAATGAAGATTTGGGAAAGGGATTGGAGA
GAAAGATTCTCAAAGATTTAGGATTGTAA
Antitoxin
Download Length: 126 a.a. Molecular weight: 14089.23 Da Isoelectric Point: 4.7873
>AT25577 WP_000921490.1 NC_015875:899156-899533 [Streptococcus pseudopneumoniae IS7493]
MLKTYPAIFHKEGTGYWVEFPEFGGGTEGKNIEEAMKNAREMLENVLASYIDEGMALPTPSDILKIEVSDGFVSMIQVDP
APFVRSNKAIRKNVTVPEWLVRLADREKINYSEVLAQALEKKLQV
MLKTYPAIFHKEGTGYWVEFPEFGGGTEGKNIEEAMKNAREMLENVLASYIDEGMALPTPSDILKIEVSDGFVSMIQVDP
APFVRSNKAIRKNVTVPEWLVRLADREKINYSEVLAQALEKKLQV
Download Length: 378 bp
>AT25577 NC_015875:899156-899533 [Streptococcus pseudopneumoniae IS7493]
ATGTTAAAAACGTATCCAGCTATTTTTCATAAAGAAGGAACAGGATATTGGGTAGAATTTCCAGAATTTGGTGGTGGTAC
AGAAGGAAAAAATATCGAAGAAGCGATGAAAAATGCTCGAGAAATGCTTGAAAATGTTTTAGCTTCTTATATCGATGAAG
GGATGGCGTTGCCTACTCCAAGTGATATTTTAAAGATTGAAGTTTCAGATGGTTTTGTATCAATGATTCAAGTTGATCCT
GCGCCTTTTGTGAGAAGTAACAAGGCGATTAGAAAGAACGTGACCGTTCCTGAATGGCTAGTTCGTCTTGCTGATCGAGA
AAAGATTAACTATTCAGAAGTTTTGGCACAAGCATTAGAGAAGAAGTTGCAAGTTTAA
ATGTTAAAAACGTATCCAGCTATTTTTCATAAAGAAGGAACAGGATATTGGGTAGAATTTCCAGAATTTGGTGGTGGTAC
AGAAGGAAAAAATATCGAAGAAGCGATGAAAAATGCTCGAGAAATGCTTGAAAATGTTTTAGCTTCTTATATCGATGAAG
GGATGGCGTTGCCTACTCCAAGTGATATTTTAAAGATTGAAGTTTCAGATGGTTTTGTATCAATGATTCAAGTTGATCCT
GCGCCTTTTGTGAGAAGTAACAAGGCGATTAGAAAGAACGTGACCGTTCCTGAATGGCTAGTTCGTCTTGCTGATCGAGA
AAAGATTAACTATTCAGAAGTTTTGGCACAAGCATTAGAGAAGAAGTTGCAAGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|