Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4034645..4035477 Replicon chromosome
Accession NZ_CP103596
Organism Escherichia coli strain 4848

Toxin (Protein)


Gene name yeeV Uniprot ID A7ZVJ9
Locus tag M5T19_RS19590 Protein ID WP_000854765.1
Coordinates 4034645..4035019 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag M5T19_RS19595 Protein ID WP_001295723.1
Coordinates 4035109..4035477 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T19_RS19570 (4030102) 4030102..4033218 + 3117 WP_000149665.1 HsdR family type I site-specific deoxyribonuclease -
M5T19_RS19575 (4033709) 4033709..4033858 - 150 Protein_3825 hypothetical protein -
M5T19_RS19580 (4033964) 4033964..4034140 - 177 WP_000839290.1 DUF957 domain-containing protein -
M5T19_RS19585 (4034157) 4034157..4034648 - 492 WP_000976842.1 DUF5983 family protein -
M5T19_RS19590 (4034645) 4034645..4035019 - 375 WP_000854765.1 TA system toxin CbtA family protein Toxin
M5T19_RS19595 (4035109) 4035109..4035477 - 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
M5T19_RS19600 (4035640) 4035640..4035861 - 222 WP_000692345.1 DUF987 domain-containing protein -
M5T19_RS19605 (4035924) 4035924..4036400 - 477 WP_001186774.1 RadC family protein -
M5T19_RS19610 (4036416) 4036416..4036889 - 474 WP_000855059.1 antirestriction protein -
M5T19_RS19615 (4037231) 4037231..4038049 - 819 WP_046464190.1 DUF932 domain-containing protein -
M5T19_RS19620 (4038167) 4038167..4038362 - 196 Protein_3834 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13970.98 Da        Isoelectric Point: 7.2909

>T255769 WP_000854765.1 NZ_CP103596:c4035019-4034645 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRHNYRTVNNITLGKYPEAK

Download         Length: 375 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT255769 WP_001295723.1 NZ_CP103596:c4035477-4035109 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A7ZVJ9

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References