Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3452379..3452997 Replicon chromosome
Accession NZ_CP103596
Organism Escherichia coli strain 4848

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag M5T19_RS16840 Protein ID WP_001291435.1
Coordinates 3452779..3452997 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag M5T19_RS16835 Protein ID WP_000344800.1
Coordinates 3452379..3452753 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T19_RS16825 (3447468) 3447468..3448661 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
M5T19_RS16830 (3448684) 3448684..3451833 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
M5T19_RS16835 (3452379) 3452379..3452753 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
M5T19_RS16840 (3452779) 3452779..3452997 + 219 WP_001291435.1 HHA domain-containing protein Toxin
M5T19_RS16845 (3453169) 3453169..3453720 + 552 WP_000102564.1 maltose O-acetyltransferase -
M5T19_RS16850 (3453836) 3453836..3454306 + 471 WP_000136192.1 YlaC family protein -
M5T19_RS16855 (3454470) 3454470..3456020 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
M5T19_RS16860 (3456062) 3456062..3456415 - 354 WP_000878140.1 DUF1428 domain-containing protein -
M5T19_RS16870 (3456794) 3456794..3457105 + 312 WP_000409911.1 MGMT family protein -
M5T19_RS16875 (3457136) 3457136..3457708 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T255765 WP_001291435.1 NZ_CP103596:3452779-3452997 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT255765 WP_000344800.1 NZ_CP103596:3452379-3452753 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References