Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1320806..1321431 Replicon chromosome
Accession NZ_CP103596
Organism Escherichia coli strain 4848

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag M5T19_RS06395 Protein ID WP_000911329.1
Coordinates 1321033..1321431 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag M5T19_RS06390 Protein ID WP_000450524.1
Coordinates 1320806..1321033 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T19_RS06365 (1316607) 1316607..1317077 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
M5T19_RS06370 (1317077) 1317077..1317649 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
M5T19_RS06375 (1317795) 1317795..1318673 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
M5T19_RS06380 (1318690) 1318690..1319724 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
M5T19_RS06385 (1319937) 1319937..1320650 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
M5T19_RS06390 (1320806) 1320806..1321033 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
M5T19_RS06395 (1321033) 1321033..1321431 + 399 WP_000911329.1 type II toxin-antitoxin system VapC family toxin Toxin
M5T19_RS06400 (1321578) 1321578..1322441 + 864 WP_001267507.1 neutral zinc metallopeptidase -
M5T19_RS06405 (1322456) 1322456..1324471 + 2016 WP_000829332.1 tRNA cytosine(34) acetyltransferase TmcA -
M5T19_RS06410 (1324545) 1324545..1325243 + 699 WP_000679812.1 esterase -
M5T19_RS06415 (1325353) 1325353..1325553 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T255755 WP_000911329.1 NZ_CP103596:1321033-1321431 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT255755 WP_000450524.1 NZ_CP103596:1320806-1321033 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References