Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 862907..863561 Replicon chromosome
Accession NZ_CP103596
Organism Escherichia coli strain 4848

Toxin (Protein)


Gene name cptA Uniprot ID F4NJ21
Locus tag M5T19_RS04225 Protein ID WP_000244772.1
Coordinates 863154..863561 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag M5T19_RS04220 Protein ID WP_000354046.1
Coordinates 862907..863173 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T19_RS04195 (858195) 858195..858938 + 744 WP_000951940.1 SDR family oxidoreductase -
M5T19_RS04200 (858995) 858995..860428 - 1434 WP_001344773.1 6-phospho-beta-glucosidase BglA -
M5T19_RS04205 (860473) 860473..860784 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
M5T19_RS04210 (860948) 860948..861607 + 660 WP_000250274.1 hemolysin III family protein -
M5T19_RS04215 (861684) 861684..862664 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
M5T19_RS04220 (862907) 862907..863173 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
M5T19_RS04225 (863154) 863154..863561 + 408 WP_000244772.1 protein YgfX Toxin
M5T19_RS04230 (863601) 863601..864122 - 522 WP_001055874.1 flavodoxin FldB -
M5T19_RS04235 (864234) 864234..865130 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
M5T19_RS04240 (865155) 865155..865865 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M5T19_RS04245 (865871) 865871..867604 + 1734 WP_000813220.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16048.02 Da        Isoelectric Point: 11.2511

>T255753 WP_000244772.1 NZ_CP103596:863154-863561 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT255753 WP_000354046.1 NZ_CP103596:862907-863173 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XYB4

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References