Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/Txe-RelB
Location 124589..125096 Replicon chromosome
Accession NC_015866
Organism Rickettsia heilongjiangensis 054

Toxin (Protein)


Gene name relB Uniprot ID G4KM08
Locus tag RH054_RS00670 Protein ID WP_014013837.1
Coordinates 124589..124852 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID G4KM09
Locus tag RH054_RS00675 Protein ID WP_014013838.1
Coordinates 124845..125096 (-) Length 84 a.a.

Genomic Context

RH054_RS00645RH054_RS08975RH054_RS00680RH054_RS00685RH054_RS00690RH054_RS07210RH054_RS09435RH054_RS00710RH054_RS00655RH054_RS00660RH054_RS00665RH054_RS00670RH054_RS00675
Location: 120090..120371 (282 bp)
Type: Others
Protein ID: WP_014013832.1
Location: 120609..121022 (414 bp)
Type: Others
Protein ID: WP_158306289.1
Location: 125236..126240 (1005 bp)
Type: Others
Protein ID: WP_014013839.1
Location: 126245..127000 (756 bp)
Type: Others
Protein ID: WP_014013840.1
Location: 127020..127619 (600 bp)
Type: Others
Protein ID: WP_014013841.1
Location: 127844..128131 (288 bp)
Type: Others
Protein ID: WP_041404299.1
Location: 128318..128707 (390 bp)
Type: Others
Protein ID: WP_197535037.1
Location: 128852..129919 (1068 bp)
Type: Others
Protein ID: WP_014013842.1
Location: 121126..122520 (1395 bp)
Type: Others
Protein ID: WP_014013834.1
Location: 122517..123173 (657 bp)
Type: Others
Protein ID: WP_014013835.1
Location: 123324..124529 (1206 bp)
Type: Others
Protein ID: WP_014013836.1
Location: 124589..124852 (264 bp)
Type: Toxin
Protein ID: WP_014013837.1
Location: 124845..125096 (252 bp)
Type: Antitoxin
Protein ID: WP_014013838.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
RH054_RS00645120090..120371+282WP_014013832.1hypothetical protein-
RH054_RS08975120609..121022+414WP_158306289.1Sca4 family protein-
RH054_RS00655121126..122520-1395WP_014013834.1lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase-
RH054_RS00660122517..123173-657WP_014013835.1lysophospholipid acyltransferase family protein-
RH054_RS00665123324..124529-1206WP_014013836.1pyridoxal phosphate-dependent aminotransferase-
RH054_RS00670124589..124852-264WP_014013837.1Txe/YoeB family addiction module toxinToxin
RH054_RS00675124845..125096-252WP_014013838.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
RH054_RS00680125236..126240+1005WP_014013839.1methyltransferase domain-containing protein-
RH054_RS00685126245..127000+756WP_014013840.1VacJ family lipoprotein-
RH054_RS00690127020..127619+600WP_014013841.1phospholipid-binding protein MlaC-
RH054_RS07210127844..128131+288WP_041404299.1ribose-phosphate pyrophosphokinase-like domain-containing protein-
RH054_RS09435128318..128707+390WP_197535037.1palindromic element RPE1 domain-containing protein-
RH054_RS00710128852..129919+1068WP_014013842.1alanine racemase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10590.39 Da        Isoelectric Point: 9.8255

>T25575 WP_014013837.1 NC_015866:c124852-124589 [Rickettsia heilongjiangensis 054]
MIEIEWTLEAAEDLVYWKKYDIKKYERIKLLIKNIQEASFTGIGKPEPLKHILSGLWSRRINHEHRLIYSVNTKQIIIYN
CRFHYKN

Download         Length: 264 bp

>T25575 NC_015866:c124852-124589 [Rickettsia heilongjiangensis 054]
ATGATTGAGATTGAGTGGACACTAGAAGCAGCGGAGGATTTAGTGTATTGGAAAAAATACGATATTAAAAAATATGAACG
TATTAAACTTCTAATAAAAAATATCCAAGAAGCATCGTTTACAGGTATAGGTAAGCCCGAACCTTTAAAACATATATTAT
CAGGTTTATGGTCACGTAGAATTAACCACGAACATAGACTAATATATTCTGTCAATACTAAACAAATTATAATATATAAT
TGTAGATTTCATTATAAGAATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9537.81 Da        Isoelectric Point: 9.4884

>AT25575 WP_014013838.1 NC_015866:c125096-124845 [Rickettsia heilongjiangensis 054]
MNSISGTSFRKNLSSVLNTVENDHVPYLIKRKNHKNIILLTEEEYESTKETLYLLSNLANANRIKKSIEQAKRGEFAKVN
LDD

Download         Length: 252 bp

>AT25575 NC_015866:c125096-124845 [Rickettsia heilongjiangensis 054]
ATGAACTCAATTAGCGGCACTTCATTTAGAAAAAACTTAAGCTCTGTACTAAATACCGTAGAAAACGATCATGTCCCTTA
TCTTATTAAAAGAAAGAATCATAAGAATATTATTCTTTTAACCGAAGAAGAATATGAATCTACAAAAGAAACATTATATT
TATTATCTAATCTGGCTAATGCGAATCGAATAAAAAAATCTATCGAACAAGCAAAAAGAGGAGAGTTTGCTAAAGTTAAT
TTAGATGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0F3RG12

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A6H3RZ38

References