Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 988019..988622 Replicon chromosome
Accession NC_015865
Organism Thermococcus sp. 4557

Toxin (Protein)


Gene name vapC Uniprot ID G0HJ24
Locus tag GQS_RS05275 Protein ID WP_014012636.1
Coordinates 988019..988411 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0HJ25
Locus tag GQS_RS05280 Protein ID WP_014012637.1
Coordinates 988398..988622 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQS_RS05255 (GQS_05240) 984176..985645 - 1470 WP_014012632.1 S-layer protein -
GQS_RS05260 (GQS_05245) 985710..986249 + 540 WP_238515829.1 DUF2391 family protein -
GQS_RS05265 (GQS_05250) 986250..987281 + 1032 WP_014012634.1 DUF3226 domain-containing protein -
GQS_RS05270 (GQS_05255) 987321..988022 + 702 WP_014012635.1 HAD family hydrolase -
GQS_RS05275 (GQS_05260) 988019..988411 - 393 WP_014012636.1 type II toxin-antitoxin system VapC family toxin Toxin
GQS_RS05280 (GQS_05265) 988398..988622 - 225 WP_014012637.1 hypothetical protein Antitoxin
GQS_RS05285 (GQS_05270) 988680..991007 - 2328 WP_014012638.1 DNA polymerase -
GQS_RS05290 (GQS_05275) 991090..991644 - 555 WP_014012639.1 hypothetical protein -
GQS_RS05295 (GQS_05280) 991748..993103 + 1356 WP_014012640.1 RsmB/NOP family class I SAM-dependent RNA methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-120)

Antitoxin

Putative antitoxin VapB3-like

(1-74)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14494.66 Da        Isoelectric Point: 4.4255

>T25574 WP_014012636.1 NC_015865:c988411-988019 [Thermococcus sp. 4557]
VIVVDASVLVRVLLKEPGWEEIEIDSSTATLDYAFVEGTNAIWKAIRRGRATEEAGRNLITVLKLIGEGMLTFEAQNFFE
RGLEIALGENITIYDALYIALAEALKADFLTADEKQYLAAKNYVNARLLR

Download         Length: 393 bp

>T25574 NC_015865:c988411-988019 [Thermococcus sp. 4557]
GTGATAGTCGTTGATGCCTCGGTTCTCGTCAGGGTTCTCCTCAAGGAACCGGGCTGGGAGGAGATTGAAATCGATTCCAG
CACGGCGACGCTGGACTATGCCTTCGTTGAAGGAACGAACGCTATATGGAAGGCCATTAGGAGGGGTAGAGCCACCGAAG
AGGCCGGCAGGAACCTTATAACCGTCCTCAAGCTCATCGGGGAGGGCATGCTTACGTTTGAGGCGCAAAACTTCTTCGAG
AGGGGGCTGGAAATAGCATTGGGTGAGAACATTACCATCTACGATGCCCTTTACATAGCCCTGGCCGAGGCACTGAAGGC
GGATTTTCTGACTGCGGATGAGAAACAGTATCTGGCCGCCAAAAATTATGTAAATGCCAGACTCCTTCGCTAG

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8928.39 Da        Isoelectric Point: 10.2394

>AT25574 WP_014012637.1 NC_015865:c988622-988398 [Thermococcus sp. 4557]
MAIVTVRVPDELKLKMKELDINWSEEIREFIRRRIDEEERRKKLKEAMEILKRTPVSVEKGFAAKSVREDRDSR

Download         Length: 225 bp

>AT25574 NC_015865:c988622-988398 [Thermococcus sp. 4557]
ATGGCCATCGTTACTGTCCGCGTTCCCGATGAGTTGAAGCTCAAGATGAAGGAGCTTGACATAAACTGGAGCGAGGAAAT
CAGAGAGTTCATAAGAAGGCGCATAGACGAGGAAGAACGGAGAAAGAAGCTAAAAGAGGCCATGGAGATACTCAAACGCA
CGCCGGTTTCTGTTGAGAAGGGGTTTGCAGCGAAGTCCGTGAGGGAGGACCGTGATAGTCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0HJ24

Antitoxin

Source ID Structure
AlphaFold DB G0HJ25

References