Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 964379..965033 Replicon chromosome
Accession NZ_CP103592
Organism Escherichia coli O25b:H4-ST131 strain 4224

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag M5S53_RS04755 Protein ID WP_000244765.1
Coordinates 964626..965033 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag M5S53_RS04750 Protein ID WP_000354050.1
Coordinates 964379..964645 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S53_RS04730 (960467) 960467..961900 - 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -
M5S53_RS04735 (961945) 961945..962256 + 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
M5S53_RS04740 (962420) 962420..963079 + 660 WP_000250275.1 hemolysin III family protein -
M5S53_RS04745 (963156) 963156..964136 - 981 WP_000886084.1 tRNA-modifying protein YgfZ -
M5S53_RS04750 (964379) 964379..964645 + 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
M5S53_RS04755 (964626) 964626..965033 + 408 WP_000244765.1 protein YgfX Toxin
M5S53_RS04760 (965073) 965073..965594 - 522 WP_001055874.1 flavodoxin FldB -
M5S53_RS04765 (965706) 965706..966602 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
M5S53_RS04770 (966627) 966627..967337 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M5S53_RS04775 (967343) 967343..969076 + 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T255726 WP_000244765.1 NZ_CP103592:964626-965033 [Escherichia coli O25b:H4-ST131]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT255726 WP_000354050.1 NZ_CP103592:964379-964645 [Escherichia coli O25b:H4-ST131]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References