255720

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 71168..71811 Replicon plasmid pMB7603_2
Accession NZ_CP103591
Organism Escherichia coli strain 4750

Toxin (Protein)


Gene name vagD Uniprot ID V0UN72
Locus tag M5T00_RS26185 Protein ID WP_001034044.1
Coordinates 71168..71584 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B1P7N7
Locus tag M5T00_RS26190 Protein ID WP_001261286.1
Coordinates 71581..71811 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T00_RS26170 (M5T00_26170) 67570..68267 + 698 WP_223155668.1 IS1-like element IS1A family transposase -
M5T00_RS26175 (M5T00_26175) 68521..69543 - 1023 WP_000361402.1 helicase UvrD -
M5T00_RS26180 (M5T00_26180) 69528..71093 - 1566 WP_001128474.1 AAA family ATPase -
M5T00_RS26185 (M5T00_26185) 71168..71584 - 417 WP_001034044.1 type II toxin-antitoxin system VapC family toxin Toxin
M5T00_RS26190 (M5T00_26190) 71581..71811 - 231 WP_001261286.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
M5T00_RS26195 (M5T00_26195) 72192..75986 + 3795 WP_001144732.1 hypothetical protein -
M5T00_RS26200 (M5T00_26200) 76031..76447 - 417 WP_001034046.1 type II toxin-antitoxin system VapC family toxin -
M5T00_RS26205 (M5T00_26205) 76444..76674 - 231 WP_001261278.1 type II toxin-antitoxin system VapB family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - senB 1..82743 82743


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15232.66 Da        Isoelectric Point: 6.8536

>T255720 WP_001034044.1 NZ_CP103591:c71584-71168 [Escherichia coli]
VNKIYMLDTNICSFIMREQPEALLKHLEQSVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCERLDAVLPWDRA
AVDATTEIKVALRLAGTPIGPNDTAIAGHAIAACAILVTNNVREFERVPGLVLEDWVR

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8747.86 Da        Isoelectric Point: 4.3775

>AT255720 WP_001261286.1 NZ_CP103591:c71811-71581 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLELEKADPDFMTEREDVVSDEGRVNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CHW1

Antitoxin

Source ID Structure
AlphaFold DB A0A829CKZ6

References