255713

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4376337..4377151 Replicon chromosome
Accession NZ_CP103589
Organism Escherichia coli strain 4750

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag M5T00_RS21250 Protein ID WP_001054376.1
Coordinates 4376337..4376594 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID S1NWL7
Locus tag M5T00_RS21255 Protein ID WP_001540600.1
Coordinates 4376606..4377151 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T00_RS21225 (4371625) 4371625..4372731 + 1107 WP_001774143.1 N-acetylneuraminate epimerase -
M5T00_RS21230 (4372796) 4372796..4373776 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
M5T00_RS21235 (4373886) 4373886..4374091 + 206 Protein_4159 HNH endonuclease -
M5T00_RS21240 (4374359) 4374359..4375599 - 1241 Protein_4160 helicase YjhR -
M5T00_RS21245 (4375715) 4375715..4375846 + 132 WP_001309182.1 hypothetical protein -
M5T00_RS21250 (4376337) 4376337..4376594 + 258 WP_001054376.1 YjhX family toxin Toxin
M5T00_RS21255 (4376606) 4376606..4377151 + 546 WP_001540600.1 N-acetyltransferase Antitoxin
M5T00_RS21260 (4377207) 4377207..4377953 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
M5T00_RS21265 (4378122) 4378122..4378340 + 219 Protein_4165 hypothetical protein -
M5T00_RS21270 (4378378) 4378378..4378494 + 117 Protein_4166 VOC family protein -
M5T00_RS21275 (4378739) 4378739..4379860 + 1122 WP_000010829.1 M42 family metallopeptidase -
M5T00_RS21280 (4379857) 4379857..4380135 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
M5T00_RS21285 (4380147) 4380147..4381460 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimI / fimA / fimE / fimB 4366123..4385375 19252


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T255713 WP_001054376.1 NZ_CP103589:4376337-4376594 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19926.87 Da        Isoelectric Point: 6.3277

>AT255713 WP_001540600.1 NZ_CP103589:4376606-4377151 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFGKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB S1NWL7

References