Detailed information of TA system TA025571

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): AbkB-shpB/BrnT-BrnA
• Location: 3872322..3872874
• Replicon: chromosome
• Accession: NC_015856
• Organism: Collimonas fungivorans Ter331

Toxin (Protein)

• Gene name: AbkB
• Uniprot ID: G0AAC3
• Locus tag: CFU_RS17115
• Protein ID: WP_014007289.1
• Coordinates: 3872322..3872618 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: shpB
• Uniprot ID: -
• Locus tag: CFU_RS17120
• Protein ID: WP_041742263.1
• Coordinates: 3872602..3872874 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CFU_RS17100	3868609..3869886	-	1278	WP_202946125.1	SGNH/GDSL hydrolase family protein	-
CFU_RS17105	3870273..3870929	+	657	WP_014007287.1	response regulator transcription factor	-
CFU_RS17110	3870926..3872239	+	1314	WP_014007288.1	two-component sensor histidine kinase	-
CFU_RS17115	3872322..3872618	+	297	WP_014007289.1	BrnT family toxin	Toxin
CFU_RS17120	3872602..3872874	+	273	WP_041742263.1	BrnA antitoxin family protein	Antitoxin
CFU_RS17125	3872982..3874463	+	1482	WP_041742264.1	DegQ family serine endoprotease	-
CFU_RS17130	3874490..3874792	+	303	WP_041742265.1	hypothetical protein	-
CFU_RS17135	3875242..3875667	+	426	WP_041742266.1	YciI family protein	-
CFU_RS17140	3875719..3876243	+	525	WP_014007293.1	SRPBCC family protein	-
CFU_RS17145	3876331..3876735	+	405	WP_202946161.1	VOC family protein	-
CFU_RS17150	3876792..3877019	-	228	WP_014007295.1	hypothetical protein	-
CFU_RS17155	3877067..3877543	-	477	WP_014007296.1	Lrp/AsnC family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (8-90)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (27-83)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11385.77 Da
• Isoelectric Point: 6.6458

>T25571 WP_014007289.1 NC_015856:3872322-3872618 [Collimonas fungivorans Ter331]
MELQLFAWDEAKNESNRRKHGVSFEAATLVFDDPLHLTRQDRVENNEQRWQTIGMVSGVTLLLVAHTWHEAESGSEHIRI
ISARRATKLERKIYEQGT

Nucleotide

• Length: 297 bp

>T25571 NC_015856:3872322-3872618 [Collimonas fungivorans Ter331]
TTGGAGTTACAATTGTTTGCATGGGATGAGGCCAAAAACGAGAGTAACCGGCGCAAACATGGCGTCAGTTTCGAGGCTGC
GACACTTGTCTTTGACGACCCTTTGCATCTCACCAGGCAAGATCGTGTCGAAAACAACGAGCAACGATGGCAGACCATCG
GCATGGTCAGCGGCGTCACCTTGTTGTTGGTTGCCCATACCTGGCACGAAGCAGAAAGCGGTTCGGAACATATCCGCATC
ATCTCCGCGCGACGCGCGACAAAGCTGGAAAGGAAAATCTATGAACAAGGTACCTGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10385.92 Da
• Isoelectric Point: 9.9611

>AT25571 WP_041742263.1 NC_015856:3872602-3872874 [Collimonas fungivorans Ter331]
MNKVPESIRKELAALAAKPESDIDFSDLPATTKQDWQGAVRGKFYRPVKQQLTVRIDADVVEWLKEEGKGYQSRMNDILR
TAMLDKVRHR

Nucleotide

• Length: 273 bp

>AT25571 NC_015856:3872602-3872874 [Collimonas fungivorans Ter331]
ATGAACAAGGTACCTGAATCTATCCGCAAAGAACTGGCGGCATTGGCAGCCAAGCCAGAGAGCGATATCGATTTCTCCGA
CCTCCCGGCCACCACCAAACAGGACTGGCAAGGCGCAGTCCGCGGGAAATTCTATCGCCCCGTCAAACAACAGCTGACTG
TACGCATTGACGCCGATGTCGTGGAGTGGCTCAAGGAAGAAGGAAAAGGTTACCAAAGCCGCATGAACGATATCTTGCGG
ACAGCCATGCTGGACAAGGTTCGTCACCGTTAG

Structures

Toxin

• AlphaFold DB: G0AAC3