Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3737033..3737651 Replicon chromosome
Accession NZ_CP103589
Organism Escherichia coli strain 4750

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag M5T00_RS18210 Protein ID WP_001291435.1
Coordinates 3737433..3737651 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag M5T00_RS18205 Protein ID WP_000344800.1
Coordinates 3737033..3737407 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T00_RS18195 (3732122) 3732122..3733315 + 1194 WP_001538394.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
M5T00_RS18200 (3733338) 3733338..3736487 + 3150 WP_001132480.1 efflux RND transporter permease AcrB -
M5T00_RS18205 (3737033) 3737033..3737407 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
M5T00_RS18210 (3737433) 3737433..3737651 + 219 WP_001291435.1 HHA domain-containing protein Toxin
M5T00_RS18215 (3737824) 3737824..3738375 + 552 WP_000102539.1 maltose O-acetyltransferase -
M5T00_RS18220 (3738491) 3738491..3738961 + 471 WP_000136192.1 YlaC family protein -
M5T00_RS18225 (3739125) 3739125..3740675 + 1551 WP_001538392.1 cyclic-guanylate-specific phosphodiesterase PdeB -
M5T00_RS18230 (3740717) 3740717..3741070 - 354 WP_000878140.1 DUF1428 domain-containing protein -
M5T00_RS18240 (3741449) 3741449..3741760 + 312 WP_000409908.1 MGMT family protein -
M5T00_RS18245 (3741791) 3741791..3742363 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T255705 WP_001291435.1 NZ_CP103589:3737433-3737651 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT255705 WP_000344800.1 NZ_CP103589:3737033-3737407 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References