Detailed information of TA system TA025569

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3767644..3768217
• Replicon: chromosome
• Accession: NC_015856
• Organism: Collimonas fungivorans Ter331

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: CFU_RS16600
• Protein ID: WP_041743605.1
• Coordinates: 3767644..3767826 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: G0AAA6
• Locus tag: CFU_RS16605
• Protein ID: WP_014007193.1
• Coordinates: 3767834..3768217 (+)
• Length: 128 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CFU_RS16570	3762678..3762998	+	321	WP_041742225.1	ribbon-helix-helix domain-containing protein	-
CFU_RS16575	3762995..3763315	-	321	WP_041742226.1	quaternary ammonium compound efflux SMR transporter SugE	-
CFU_RS16580	3763474..3763797	+	324	WP_041742227.1	YnfA family protein	-
CFU_RS16585	3763817..3764821	-	1005	WP_041742228.1	sodium:calcium antiporter	-
CFU_RS16590	3765285..3766187	+	903	WP_014007191.1	lipid A hydroxylase LpxO	-
CFU_RS16595	3766333..3767397	+	1065	WP_014007192.1	purine nucleoside permease	-
CFU_RS16600	3767644..3767826	+	183	WP_041743605.1	type II toxin-antitoxin system HicA family toxin	Toxin
CFU_RS16605	3767834..3768217	+	384	WP_014007193.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
CFU_RS16610	3768546..3769037	+	492	WP_014007194.1	type VI secretion system tube protein Hcp	-
CFU_RS16615	3769101..3770426	-	1326	WP_014007195.1	fumarylacetoacetase	-
CFU_RS16620	3770384..3771688	-	1305	WP_014007196.1	homogentisate 1,2-dioxygenase	-
CFU_RS16625	3771709..3773064	-	1356	WP_014007197.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-121)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6601.78 Da
• Isoelectric Point: 11.5305

>T25569 WP_041743605.1 NC_015856:3767644-3767826 [Collimonas fungivorans Ter331]
MNSTHIIRQLKAAGWKHVSTRGSHHKYRHPVTGKSVIVPHPKKDLALGTAESILKLAGLK

Nucleotide

• Length: 183 bp

>T25569 NC_015856:3767644-3767826 [Collimonas fungivorans Ter331]
ATGAACAGCACACACATCATCAGGCAACTGAAAGCGGCCGGCTGGAAGCATGTTTCCACCCGTGGCAGCCACCACAAATA
CCGTCATCCCGTCACCGGAAAATCGGTAATTGTTCCGCATCCGAAGAAAGACCTGGCCCTGGGAACCGCCGAGAGCATCC
TGAAACTCGCTGGACTGAAATGA

Antitoxin

Protein

• Length: 128 a.a.
• Molecular weight: 14224.20 Da
• Isoelectric Point: 4.7025

>AT25569 WP_014007193.1 NC_015856:3767834-3768217 [Collimonas fungivorans Ter331]
MLYPLYVWKDKDSAYGARFPDLPGVFTAADELNDLPAMAQEAAETMYEGEAHIPEASSIEKWRDMADYAGGFWMLVNIDR
SKINTKPVRLNISLPENLLRDIDAFAKSHQLTRSGFLAQAALKAMAQ

Nucleotide

• Length: 384 bp

>AT25569 NC_015856:3767834-3768217 [Collimonas fungivorans Ter331]
ATGTTATATCCGCTTTATGTATGGAAGGACAAAGACAGCGCTTATGGCGCCCGCTTCCCGGATCTGCCGGGCGTGTTTAC
CGCCGCCGACGAATTGAACGATCTTCCGGCAATGGCGCAGGAAGCTGCTGAAACCATGTATGAGGGTGAAGCGCATATTC
CCGAGGCGTCATCCATCGAGAAATGGAGGGATATGGCGGACTACGCTGGCGGTTTCTGGATGCTGGTCAATATCGATCGC
TCGAAAATCAACACCAAGCCTGTGCGGCTCAACATCTCCTTACCGGAAAACCTTTTACGCGACATCGATGCATTCGCCAA
ATCGCATCAGTTGACCCGATCCGGATTCCTGGCCCAAGCCGCGCTGAAAGCAATGGCCCAATAA

Structures

Antitoxin

• AlphaFold DB: G0AAA6