Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4733257..4733960 Replicon chromosome
Accession NZ_CP103586
Organism Klebsiella pneumoniae strain 4737

Toxin (Protein)


Gene name ykfI Uniprot ID A0A939NMR5
Locus tag M5T07_RS23265 Protein ID WP_071994632.1
Coordinates 4733257..4733598 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A939NIK9
Locus tag M5T07_RS23270 Protein ID WP_032434296.1
Coordinates 4733619..4733960 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T07_RS23255 (4729572) 4729572..4730441 + 870 WP_023317468.1 HNH endonuclease -
M5T07_RS23260 (4731032) 4731032..4733065 + 2034 WP_050598589.1 hypothetical protein -
M5T07_RS23265 (4733257) 4733257..4733598 - 342 WP_071994632.1 TA system toxin CbtA family protein Toxin
M5T07_RS23270 (4733619) 4733619..4733960 - 342 WP_032434296.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
M5T07_RS23275 (4733971) 4733971..4734513 - 543 WP_032434298.1 DNA repair protein RadC -
M5T07_RS23280 (4734526) 4734526..4734966 - 441 WP_032434300.1 antirestriction protein -
M5T07_RS23285 (4734997) 4734997..4735818 - 822 WP_032434301.1 DUF932 domain-containing protein -
M5T07_RS23290 (4735938) 4735938..4736411 - 474 WP_032434303.1 hypothetical protein -
M5T07_RS23295 (4736483) 4736483..4736935 - 453 WP_032410767.1 hypothetical protein -
M5T07_RS23300 (4736971) 4736971..4737687 - 717 WP_032434305.1 WYL domain-containing protein -
M5T07_RS23305 (4737931) 4737931..4738805 - 875 Protein_4567 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4721554..4767227 45673


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12789.77 Da        Isoelectric Point: 9.6552

>T255688 WP_071994632.1 NZ_CP103586:c4733598-4733257 [Klebsiella pneumoniae]
MKTLPATTPQAVTLCLSSVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRKGF
NWQEHSPYLRAVDILRARQATGLLRRSRKNAVR

Download         Length: 342 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12893.40 Da        Isoelectric Point: 5.9612

>AT255688 WP_032434296.1 NZ_CP103586:c4733960-4733619 [Klebsiella pneumoniae]
MKSTDSENDSFLKWGLNRNVTPCFGARLVQEGNRLHYLADRASITGEFSNAESLKLDEVFPHFISQMESMLTTGEMNPRH
AHFFTLYHNGFTCEADTLGSYGYVYIAVYPTQR

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References