Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/FR47-DUF1778
Location 35976..36771 Replicon plasmid pMB7868_2
Accession NZ_CP103584
Organism Klebsiella pneumoniae strain 1498

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag M5S97_RS27090 Protein ID WP_064383561.1
Coordinates 36253..36771 (+) Length 173 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID -
Locus tag M5S97_RS27085 Protein ID WP_064383558.1
Coordinates 35976..36248 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S97_RS27060 (M5S97_27060) 31618..32979 - 1362 WP_064383547.1 DnaB-like helicase C-terminal domain-containing protein -
M5S97_RS27065 (M5S97_27065) 33024..33764 - 741 WP_064383550.1 hypothetical protein -
M5S97_RS27070 (M5S97_27070) 33944..34420 + 477 WP_130573867.1 hypothetical protein -
M5S97_RS27075 (M5S97_27075) 34622..34996 - 375 WP_064383554.1 hypothetical protein -
M5S97_RS27080 (M5S97_27080) 35002..35667 - 666 WP_064383556.1 AAA family ATPase -
M5S97_RS27085 (M5S97_27085) 35976..36248 + 273 WP_064383558.1 DUF1778 domain-containing protein Antitoxin
M5S97_RS27090 (M5S97_27090) 36253..36771 + 519 WP_064383561.1 GNAT family N-acetyltransferase Toxin
M5S97_RS27095 (M5S97_27095) 36903..37112 + 210 WP_064383564.1 hypothetical protein -
M5S97_RS27100 (M5S97_27100) 37335..37586 - 252 WP_064383566.1 hypothetical protein -
M5S97_RS27105 (M5S97_27105) 37583..38275 - 693 WP_064383568.1 hypothetical protein -
M5S97_RS27110 (M5S97_27110) 38286..38600 - 315 WP_009484919.1 hypothetical protein -
M5S97_RS27115 (M5S97_27115) 38683..40224 - 1542 WP_130573866.1 tail fiber domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..111561 111561


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(50-150)

Antitoxin

Vibrio phage ICP1, Orf50

(2-88)


Sequences

Toxin        


Download         Length: 173 a.a.        Molecular weight: 19297.07 Da        Isoelectric Point: 6.4627

>T255676 WP_064383561.1 NZ_CP103584:36253-36771 [Klebsiella pneumoniae]
VNTYDIEPIQKDFPYDISSFDCGNEALNLFLSEHLQRQDEKQILRGYVYLEYGSGLPKVLGFFTLAGGSFERSRFPSKSQ
QKKIPYTNTPCIILGRLAVDKTVQRQGIGEMLVVEAAKVVLQAANAIGLHGMFVDAKNESACKFYENLGFTRLIGDNENL
FFYPTSKIAQLP

Download         Length: 519 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10317.85 Da        Isoelectric Point: 6.9840

>AT255676 WP_064383558.1 NZ_CP103584:35976-36248 [Klebsiella pneumoniae]
MPTLKKERIDIRLTDEAKSVIEEAAILSNLSVSQFVISSAAERATEVIEQHRRIVLCEDSWKLVMDAINNPDQPNDRMKR
AAERLKNLRT

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References