Detailed information of TA system TA255673

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4898537..4900218
• Replicon: chromosome
• Accession: NZ_CP103582
• Organism: Klebsiella pneumoniae strain 1498

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: J2XCI1
• Locus tag: M5S97_RS24010
• Protein ID: WP_004146663.1
• Coordinates: 4898537..4899454 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: M5S97_RS24015
• Protein ID: WP_023285713.1
• Coordinates: 4899460..4900218 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M5S97_RS23990 (M5S97_23990)	4893843..4895363	+	1521	WP_004210021.1	sugar ABC transporter ATP-binding protein	-
M5S97_RS23995 (M5S97_23995)	4895360..4896358	+	999	WP_002885172.1	ribose ABC transporter permease	-
M5S97_RS24000 (M5S97_24000)	4896389..4897330	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
M5S97_RS24005 (M5S97_24005)	4897405..4898412	+	1008	WP_004178300.1	carbohydrate kinase family protein	-
M5S97_RS24010 (M5S97_24010)	4898537..4899454	-	918	WP_004146663.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
M5S97_RS24015 (M5S97_24015)	4899460..4900218	-	759	WP_023285713.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
M5S97_RS24020 (M5S97_24020)	4900304..4901032	-	729	WP_004177810.1	response regulator transcription factor	-
M5S97_RS24025 (M5S97_24025)	4901305..4903452	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
M5S97_RS24030 (M5S97_24030)	4903682..4904368	+	687	WP_004151733.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (95-246)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34659.10 Da
• Isoelectric Point: 5.4707

>T255673 WP_004146663.1 NZ_CP103582:c4899454-4898537 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28575.99 Da
• Isoelectric Point: 10.1536

>AT255673 WP_023285713.1 NZ_CP103582:c4900218-4899460 [Klebsiella pneumoniae]
MAKKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

Structures

Toxin

• AlphaFold DB: J2XCI1