Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4737460..4737976 Replicon chromosome
Accession NZ_CP103582
Organism Klebsiella pneumoniae strain 1498

Toxin (Protein)


Gene name relE Uniprot ID A0A085DK79
Locus tag M5S97_RS23200 Protein ID WP_009309309.1
Coordinates 4737460..4737744 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag M5S97_RS23205 Protein ID WP_002886901.1
Coordinates 4737734..4737976 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S97_RS23175 (M5S97_23175) 4732936..4733199 - 264 WP_228985702.1 PTS sugar transporter subunit IIB -
M5S97_RS23180 (M5S97_23180) 4733329..4733502 + 174 WP_032409292.1 hypothetical protein -
M5S97_RS23185 (M5S97_23185) 4733505..4734248 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
M5S97_RS23190 (M5S97_23190) 4734605..4736743 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
M5S97_RS23195 (M5S97_23195) 4736992..4737456 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
M5S97_RS23200 (M5S97_23200) 4737460..4737744 - 285 WP_009309309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5S97_RS23205 (M5S97_23205) 4737734..4737976 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M5S97_RS23210 (M5S97_23210) 4738054..4739964 - 1911 WP_004152270.1 PRD domain-containing protein -
M5S97_RS23215 (M5S97_23215) 4739987..4741141 - 1155 WP_002886900.1 lactonase family protein -
M5S97_RS23220 (M5S97_23220) 4741208..4741948 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11141.99 Da        Isoelectric Point: 10.3787

>T255672 WP_009309309.1 NZ_CP103582:c4737744-4737460 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT255672 WP_002886901.1 NZ_CP103582:c4737976-4737734 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085DK79

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References