Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PanAT/DUF4065(antitoxin) |
| Location | 3959562..3960535 | Replicon | chromosome |
| Accession | NZ_CP103582 | ||
| Organism | Klebsiella pneumoniae strain 1498 | ||
Toxin (Protein)
| Gene name | panT | Uniprot ID | - |
| Locus tag | M5S97_RS19475 | Protein ID | WP_072040111.1 |
| Coordinates | 3960128..3960535 (+) | Length | 136 a.a. |
Antitoxin (Protein)
| Gene name | panA | Uniprot ID | - |
| Locus tag | M5S97_RS19470 | Protein ID | WP_040215292.1 |
| Coordinates | 3959562..3960131 (+) | Length | 190 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M5S97_RS19430 (M5S97_19430) | 3955560..3955700 | - | 141 | WP_004142684.1 | hypothetical protein | - |
| M5S97_RS19435 (M5S97_19435) | 3956025..3956195 | + | 171 | WP_002892370.1 | hypothetical protein | - |
| M5S97_RS19440 (M5S97_19440) | 3956274..3956675 | - | 402 | WP_002892366.1 | hydroxyisourate hydrolase | - |
| M5S97_RS19445 (M5S97_19445) | 3957071..3957364 | - | 294 | WP_002892360.1 | hypothetical protein | - |
| M5S97_RS19450 (M5S97_19450) | 3957642..3957807 | + | 166 | Protein_3816 | hypothetical protein | - |
| M5S97_RS19455 (M5S97_19455) | 3958306..3958698 | - | 393 | WP_052455502.1 | KilA-N domain-containing protein | - |
| M5S97_RS19460 (M5S97_19460) | 3958781..3959029 | + | 249 | WP_032410641.1 | AlpA family phage regulatory protein | - |
| M5S97_RS19465 (M5S97_19465) | 3959130..3959393 | + | 264 | WP_226323891.1 | hypothetical protein | - |
| M5S97_RS19470 (M5S97_19470) | 3959562..3960131 | + | 570 | WP_040215292.1 | Panacea domain-containing protein | Antitoxin |
| M5S97_RS19475 (M5S97_19475) | 3960128..3960535 | + | 408 | WP_072040111.1 | hypothetical protein | Toxin |
| M5S97_RS19480 (M5S97_19480) | 3960568..3960951 | - | 384 | WP_141408244.1 | Rap1a/Tai family immunity protein | - |
| M5S97_RS19485 (M5S97_19485) | 3960954..3963521 | - | 2568 | WP_032436809.1 | hypothetical protein | - |
| M5S97_RS19490 (M5S97_19490) | 3963514..3965241 | - | 1728 | WP_032436810.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 3959130..3979046 | 19916 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 136 a.a. Molecular weight: 15154.21 Da Isoelectric Point: 5.9868
>T255669 WP_072040111.1 NZ_CP103582:3960128-3960535 [Klebsiella pneumoniae]
MTQQYAPYRKGTVLAPVGGSDHLHIICNDPVHYPIHGCDCVLVVNISSVYPPPAYSDPACILHAGEHPFVFHDSFVYYED
AIVWKVPNVISREQSGELTPHADMEENVLQRVLSGFEASDFTNPKILKFYRAHCI
MTQQYAPYRKGTVLAPVGGSDHLHIICNDPVHYPIHGCDCVLVVNISSVYPPPAYSDPACILHAGEHPFVFHDSFVYYED
AIVWKVPNVISREQSGELTPHADMEENVLQRVLSGFEASDFTNPKILKFYRAHCI
Download Length: 408 bp
Antitoxin
Download Length: 190 a.a. Molecular weight: 21591.42 Da Isoelectric Point: 4.9915
>AT255669 WP_040215292.1 NZ_CP103582:3959562-3960131 [Klebsiella pneumoniae]
MYSESKTAQMAGYLLLKRGGRMAYIKLMKLLYLADREYMITYGDSMTGDRAVSMNNGPVLSRTYDLLKSGSPEEESPWDD
WIAGEADFEVSLKKRVNGLDDDDAFDELSKANKRILDKVFDEYGQYKRFELCDLTHRVCAEWQNPHGSSVPISPKDILMA
GGKSESEADELIRHMRERDALKQFSRQLA
MYSESKTAQMAGYLLLKRGGRMAYIKLMKLLYLADREYMITYGDSMTGDRAVSMNNGPVLSRTYDLLKSGSPEEESPWDD
WIAGEADFEVSLKKRVNGLDDDDAFDELSKANKRILDKVFDEYGQYKRFELCDLTHRVCAEWQNPHGSSVPISPKDILMA
GGKSESEADELIRHMRERDALKQFSRQLA
Download Length: 570 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|