Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2612393..2613981 Replicon chromosome
Accession NZ_CP103582
Organism Klebsiella pneumoniae strain 1498

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag M5S97_RS12795 Protein ID WP_002904792.1
Coordinates 2612393..2613715 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag M5S97_RS12800 Protein ID WP_002904790.1
Coordinates 2613715..2613981 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S97_RS12780 (M5S97_12780) 2607449..2609950 + 2502 WP_259382549.1 fimbria/pilus outer membrane usher protein -
M5S97_RS12785 (M5S97_12785) 2609938..2610942 + 1005 WP_065519760.1 fimbrial protein -
M5S97_RS12790 (M5S97_12790) 2611084..2612376 + 1293 WP_032423495.1 glycoside hydrolase family 10 protein -
M5S97_RS12795 (M5S97_12795) 2612393..2613715 - 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
M5S97_RS12800 (M5S97_12800) 2613715..2613981 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
M5S97_RS12805 (M5S97_12805) 2614247..2614573 - 327 WP_002904788.1 hydroxyisourate hydrolase -
M5S97_RS12810 (M5S97_12810) 2614570..2615070 - 501 WP_065519759.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
M5S97_RS12815 (M5S97_12815) 2615048..2616427 - 1380 WP_004176204.1 nucleobase:cation symporter-2 family protein -
M5S97_RS12820 (M5S97_12820) 2616773..2617927 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
M5S97_RS12825 (M5S97_12825) 2617908..2618831 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T255667 WP_002904792.1 NZ_CP103582:c2613715-2612393 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT255667 WP_002904790.1 NZ_CP103582:c2613981-2613715 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References