Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 812342..812999 Replicon chromosome
Accession NZ_CP103582
Organism Klebsiella pneumoniae strain 1498

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag M5S97_RS04040 Protein ID WP_002916310.1
Coordinates 812589..812999 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag M5S97_RS04035 Protein ID WP_002916312.1
Coordinates 812342..812608 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S97_RS04010 (M5S97_04010) 807498..808931 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
M5S97_RS04015 (M5S97_04015) 809050..809778 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
M5S97_RS04020 (M5S97_04020) 809828..810139 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
M5S97_RS04025 (M5S97_04025) 810303..810962 + 660 WP_002916317.1 hemolysin III family protein -
M5S97_RS04030 (M5S97_04030) 811113..812096 - 984 WP_141408279.1 tRNA-modifying protein YgfZ -
M5S97_RS04035 (M5S97_04035) 812342..812608 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
M5S97_RS04040 (M5S97_04040) 812589..812999 + 411 WP_002916310.1 protein YgfX Toxin
M5S97_RS04045 (M5S97_04045) 813006..813527 - 522 WP_004144730.1 flavodoxin FldB -
M5S97_RS04050 (M5S97_04050) 813628..814524 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
M5S97_RS04055 (M5S97_04055) 814547..815260 + 714 WP_071081169.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M5S97_RS04060 (M5S97_04060) 815266..816999 + 1734 WP_071081170.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T255662 WP_002916310.1 NZ_CP103582:812589-812999 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT255662 WP_002916312.1 NZ_CP103582:812342-812608 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References