Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 734159..734934 Replicon chromosome
Accession NZ_CP103582
Organism Klebsiella pneumoniae strain 1498

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag M5S97_RS03650 Protein ID WP_060568463.1
Coordinates 734449..734934 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag M5S97_RS03645 Protein ID WP_004150912.1
Coordinates 734159..734452 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S97_RS03625 (M5S97_03625) 729367..729969 - 603 WP_004174410.1 short chain dehydrogenase -
M5S97_RS03630 (M5S97_03630) 730067..730978 + 912 WP_023342207.1 LysR family transcriptional regulator -
M5S97_RS03635 (M5S97_03635) 730979..732127 - 1149 WP_016947441.1 PLP-dependent aspartate aminotransferase family protein -
M5S97_RS03640 (M5S97_03640) 732138..733514 - 1377 WP_004174417.1 pyridoxal-phosphate dependent enzyme -
M5S97_RS03645 (M5S97_03645) 734159..734452 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
M5S97_RS03650 (M5S97_03650) 734449..734934 + 486 WP_060568463.1 GNAT family N-acetyltransferase Toxin
M5S97_RS03655 (M5S97_03655) 735647..736615 - 969 WP_080465744.1 IS5 family transposase -
M5S97_RS03665 (M5S97_03665) 737203..737916 - 714 WP_002916694.1 DUF554 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 735647..736570 923


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17602.64 Da        Isoelectric Point: 8.1629

>T255661 WP_060568463.1 NZ_CP103582:734449-734934 [Klebsiella pneumoniae]
MILAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRHNMPDPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT255661 WP_004150912.1 NZ_CP103582:734159-734452 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References