Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 11119..11762 Replicon plasmid pMB7964_1
Accession NZ_CP103580
Organism Klebsiella pneumoniae strain 4014

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag M5S61_RS25755 Protein ID WP_016236302.1
Coordinates 11346..11762 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D5KTK7
Locus tag M5S61_RS25750 Protein ID WP_001261282.1
Coordinates 11119..11349 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S61_RS25725 (M5S61_25725) 6835..7092 - 258 WP_023292103.1 hypothetical protein -
M5S61_RS25730 (M5S61_25730) 7570..8298 + 729 Protein_6 CSS-motif domain-containing protein -
M5S61_RS25735 (M5S61_25735) 8314..9150 + 837 WP_032439674.1 EAL domain-containing protein -
M5S61_RS25740 (M5S61_25740) 9768..10199 - 432 WP_174805835.1 hypothetical protein -
M5S61_RS25745 (M5S61_25745) 10740..11162 - 423 WP_046624301.1 hypothetical protein -
M5S61_RS25750 (M5S61_25750) 11119..11349 + 231 WP_001261282.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
M5S61_RS25755 (M5S61_25755) 11346..11762 + 417 WP_016236302.1 type II toxin-antitoxin system VapC family toxin Toxin
M5S61_RS25760 (M5S61_25760) 11836..13398 + 1563 WP_004206609.1 AAA family ATPase -
M5S61_RS25765 (M5S61_25765) 13383..14405 + 1023 WP_032439672.1 helicase UvrD -
M5S61_RS25770 (M5S61_25770) 14950..15858 + 909 WP_032439686.1 HNH endonuclease -
M5S61_RS25775 (M5S61_25775) 16044..16394 - 351 WP_004187110.1 DUF305 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid sul2 / aph(3'')-Ib / aph(6)-Id / blaTEM-1B / blaCTX-M-15 / dfrA14 / blaOXA-1 / aac(6')-Ib-cr / tet(A) / qnrB1 / aac(3)-IIa - 1..170849 170849


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15091.55 Da        Isoelectric Point: 7.1084

>T255658 WP_016236302.1 NZ_CP103580:11346-11762 [Klebsiella pneumoniae]
VNKTYMLDTCICSFIMREQPEAVLKRLELAVLRGQRIVVSAITYSEMRFGATGPKASPRHVELVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8756.83 Da        Isoelectric Point: 4.4692

>AT255658 WP_001261282.1 NZ_CP103580:11119-11349 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQFEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GZG3

References