Detailed information of TA system TA255656

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4867029..4868710
• Replicon: chromosome
• Accession: NZ_CP103579
• Organism: Klebsiella pneumoniae strain 4014

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: J2XCI1
• Locus tag: M5S61_RS23840
• Protein ID: WP_004146663.1
• Coordinates: 4867029..4867946 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: M5S61_RS23845
• Protein ID: WP_004177809.1
• Coordinates: 4867952..4868710 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M5S61_RS23820 (4862335)	4862335..4863855	+	1521	WP_004210021.1	sugar ABC transporter ATP-binding protein	-
M5S61_RS23825 (4863852)	4863852..4864850	+	999	WP_002885172.1	ribose ABC transporter permease	-
M5S61_RS23830 (4864881)	4864881..4865822	+	942	WP_071081464.1	ABC transporter substrate-binding protein	-
M5S61_RS23835 (4865897)	4865897..4866904	+	1008	WP_009484222.1	carbohydrate kinase family protein	-
M5S61_RS23840 (4867029)	4867029..4867946	-	918	WP_004146663.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
M5S61_RS23845 (4867952)	4867952..4868710	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
M5S61_RS23850 (4868796)	4868796..4869524	-	729	WP_002885152.1	response regulator transcription factor	-
M5S61_RS23855 (4869797)	4869797..4871944	+	2148	WP_077598921.1	formate dehydrogenase subunit alpha	-
M5S61_RS23860 (4872174)	4872174..4872860	+	687	WP_004151733.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34659.10 Da
• Isoelectric Point: 5.4707

>T255656 WP_004146663.1 NZ_CP103579:c4867946-4867029 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT255656 WP_004177809.1 NZ_CP103579:c4868710-4867952 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

Structures

Toxin

• AlphaFold DB: J2XCI1

Antitoxin

• AlphaFold DB: A6TH05