Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4597902..4598712 Replicon chromosome
Accession NZ_CP103579
Organism Klebsiella pneumoniae strain 4014

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag M5S61_RS22590 Protein ID WP_071081553.1
Coordinates 4597902..4598435 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag M5S61_RS22595 Protein ID WP_002887278.1
Coordinates 4598446..4598712 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S61_RS22585 (4596733) 4596733..4597854 + 1122 WP_016946712.1 cupin domain-containing protein -
M5S61_RS22590 (4597902) 4597902..4598435 - 534 WP_071081553.1 type II toxin-antitoxin system toxin KacT Toxin
M5S61_RS22595 (4598446) 4598446..4598712 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
M5S61_RS22600 (4598815) 4598815..4600248 - 1434 WP_032413318.1 Cu(+)/Ag(+) sensor histidine kinase -
M5S61_RS22605 (4600238) 4600238..4600921 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
M5S61_RS22610 (4601094) 4601094..4602479 + 1386 WP_032413315.1 efflux transporter outer membrane subunit -
M5S61_RS22615 (4602497) 4602497..4602841 + 345 WP_002887266.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19798.59 Da        Isoelectric Point: 5.2614

>T255654 WP_071081553.1 NZ_CP103579:c4598435-4597902 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLATDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT255654 WP_002887278.1 NZ_CP103579:c4598712-4598446 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References