Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4344498..4345114 Replicon chromosome
Accession NZ_CP103577
Organism Enterobacter hormaechei strain 4285

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag M5S64_RS21085 Protein ID WP_077266491.1
Coordinates 4344498..4344869 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6G4MTK3
Locus tag M5S64_RS21090 Protein ID WP_015569912.1
Coordinates 4344872..4345114 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S64_RS21070 (M5S64_21070) 4341998..4342900 + 903 WP_014072386.1 formate dehydrogenase subunit beta -
M5S64_RS21075 (M5S64_21075) 4342897..4343532 + 636 WP_015569914.1 formate dehydrogenase cytochrome b556 subunit -
M5S64_RS21080 (M5S64_21080) 4343529..4344458 + 930 WP_003861956.1 formate dehydrogenase accessory protein FdhE -
M5S64_RS21085 (M5S64_21085) 4344498..4344869 - 372 WP_077266491.1 type II toxin-antitoxin system VapC family toxin Toxin
M5S64_RS21090 (M5S64_21090) 4344872..4345114 - 243 WP_015569912.1 ribbon-helix-helix domain-containing protein Antitoxin
M5S64_RS21095 (M5S64_21095) 4345313..4346233 + 921 WP_045340216.1 alpha/beta hydrolase -
M5S64_RS21100 (M5S64_21100) 4346242..4347183 - 942 WP_015569910.1 fatty acid biosynthesis protein FabY -
M5S64_RS21105 (M5S64_21105) 4347228..4347665 - 438 WP_045340215.1 D-aminoacyl-tRNA deacylase -
M5S64_RS21110 (M5S64_21110) 4347662..4348543 - 882 WP_003861949.1 virulence factor BrkB family protein -
M5S64_RS21115 (M5S64_21115) 4348537..4349136 - 600 WP_017694048.1 glucose-1-phosphatase -
M5S64_RS21120 (M5S64_21120) 4349255..4350055 - 801 WP_003861944.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13723.85 Da        Isoelectric Point: 6.4882

>T255644 WP_077266491.1 NZ_CP103577:c4344869-4344498 [Enterobacter hormaechei]
MEHMAVFDTNILIDLFNNRVEAADAIEHTASHRAISLITWMEVMVGARRHGHEAKTAAVMGAFEIIDVSRDIAERSVLLR
EKHGMKLPDAIILATAQSRKCPLISRNTKDFAGIDEVLTPYQV

Download         Length: 372 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9440.72 Da        Isoelectric Point: 4.4076

>AT255644 WP_015569912.1 NZ_CP103577:c4345114-4344872 [Enterobacter hormaechei]
MSVLAELDMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIELYLDQQSSSVIRNALGLWGDRKEDGLEYERKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6G4MTK3

References