Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4220802..4221406 Replicon chromosome
Accession NZ_CP103577
Organism Enterobacter hormaechei strain 4285

Toxin (Protein)


Gene name hicA Uniprot ID A0A2J0PXG2
Locus tag M5S64_RS20530 Protein ID WP_071788668.1
Coordinates 4221221..4221406 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag M5S64_RS20525 Protein ID WP_045339152.1
Coordinates 4220802..4221206 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S64_RS20510 (M5S64_20510) 4216342..4217160 - 819 WP_032649828.1 helix-turn-helix domain-containing protein -
M5S64_RS20515 (M5S64_20515) 4217386..4218786 + 1401 WP_017693791.1 MFS transporter -
M5S64_RS20520 (M5S64_20520) 4218797..4220746 + 1950 WP_045339155.1 glycoside hydrolase family 127 protein -
M5S64_RS20525 (M5S64_20525) 4220802..4221206 - 405 WP_045339152.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
M5S64_RS20530 (M5S64_20530) 4221221..4221406 - 186 WP_071788668.1 type II toxin-antitoxin system HicA family toxin Toxin
M5S64_RS20535 (M5S64_20535) 4221656..4223194 - 1539 WP_006808612.1 aldehyde dehydrogenase AldB -
M5S64_RS20540 (M5S64_20540) 4223361..4224245 + 885 WP_039269503.1 ROK family protein -
M5S64_RS20545 (M5S64_20545) 4224249..4226087 - 1839 WP_045339150.1 selenocysteine-specific translation elongation factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6822.05 Da        Isoelectric Point: 11.5191

>T255643 WP_071788668.1 NZ_CP103577:c4221406-4221221 [Enterobacter hormaechei]
VKSADIIAVLVSHGWKCVRTKGSHHQFRHPVQKGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Download         Length: 186 bp

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14947.72 Da        Isoelectric Point: 4.2329

>AT255643 WP_045339152.1 NZ_CP103577:c4221206-4220802 [Enterobacter hormaechei]
MFYPAYIHSDSDGSASGFFPDVPGCFFAGDSLDDAFQDARDALTAHLEALFEMDEALPLPGNVEVHLENQPDDFTGGQWL
LVDINMKQFDGRAERINITMPRRLLVKIDSFVSEHPQFGNRSAFLAEAARRVLP

Download         Length: 405 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J0PXG2

Antitoxin

Source ID Structure

References