Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3258321..3258941 Replicon chromosome
Accession NZ_CP103577
Organism Enterobacter hormaechei strain 4285

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag M5S64_RS15895 Protein ID WP_015571250.1
Coordinates 3258723..3258941 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag M5S64_RS15890 Protein ID WP_006809850.1
Coordinates 3258321..3258695 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S64_RS15880 (M5S64_15880) 3253448..3254641 + 1194 WP_017694395.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
M5S64_RS15885 (M5S64_15885) 3254664..3257810 + 3147 WP_015571248.1 multidrug efflux RND transporter permease subunit AcrB -
M5S64_RS15890 (M5S64_15890) 3258321..3258695 + 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
M5S64_RS15895 (M5S64_15895) 3258723..3258941 + 219 WP_015571250.1 HHA domain-containing protein Toxin
M5S64_RS15900 (M5S64_15900) 3259150..3259701 + 552 WP_045339381.1 maltose O-acetyltransferase -
M5S64_RS15905 (M5S64_15905) 3259818..3260285 + 468 WP_023296041.1 YlaC family protein -
M5S64_RS15910 (M5S64_15910) 3260257..3261717 - 1461 WP_045339383.1 PLP-dependent aminotransferase family protein -
M5S64_RS15915 (M5S64_15915) 3261819..3262529 + 711 WP_017383207.1 GNAT family protein -
M5S64_RS15920 (M5S64_15920) 3262526..3262666 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
M5S64_RS15925 (M5S64_15925) 3262669..3262929 - 261 WP_015571255.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T255642 WP_015571250.1 NZ_CP103577:3258723-3258941 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT255642 WP_006809850.1 NZ_CP103577:3258321-3258695 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References