Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2350514..2351253 Replicon chromosome
Accession NZ_CP103577
Organism Enterobacter hormaechei strain 4285

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag M5S64_RS11140 Protein ID WP_045339804.1
Coordinates 2350768..2351253 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag M5S64_RS11135 Protein ID WP_003857131.1
Coordinates 2350514..2350780 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S64_RS11115 (M5S64_11115) 2345990..2346976 + 987 WP_017382341.1 DUF979 domain-containing protein -
M5S64_RS11120 (M5S64_11120) 2346986..2347981 + 996 WP_045339807.1 DUF2891 domain-containing protein -
M5S64_RS11125 (M5S64_11125) 2348003..2349391 - 1389 WP_045339805.1 MFS transporter -
M5S64_RS11130 (M5S64_11130) 2349521..2350450 + 930 WP_045339929.1 LysR family transcriptional regulator -
M5S64_RS11135 (M5S64_11135) 2350514..2350780 + 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
M5S64_RS11140 (M5S64_11140) 2350768..2351253 + 486 WP_045339804.1 GNAT family N-acetyltransferase Toxin
M5S64_RS11145 (M5S64_11145) 2351304..2351873 - 570 WP_032648331.1 hypothetical protein -
M5S64_RS11150 (M5S64_11150) 2351889..2352854 - 966 WP_032648329.1 hypothetical protein -
M5S64_RS11155 (M5S64_11155) 2353123..2354526 + 1404 WP_001567368.1 ISNCY-like element ISKpn21 family transposase -
M5S64_RS11160 (M5S64_11160) 2354555..2355187 - 633 WP_001567369.1 hypothetical protein -
M5S64_RS11165 (M5S64_11165) 2355262..2356230 + 969 WP_022652343.1 IS5-like element IS903B family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17558.27 Da        Isoelectric Point: 9.9658

>T255639 WP_045339804.1 NZ_CP103577:2350768-2351253 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAMMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT255639 WP_003857131.1 NZ_CP103577:2350514-2350780 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References