Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA(toxin)
Location 1652704..1654487 Replicon chromosome
Accession NZ_CP103577
Organism Enterobacter hormaechei strain 4285

Toxin (Protein)


Gene name hipA Uniprot ID A0A2G5A822
Locus tag M5S64_RS07895 Protein ID WP_045333653.1
Coordinates 1653138..1654487 (-) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A2G5A843
Locus tag M5S64_RS07890 Protein ID WP_045333654.1
Coordinates 1652704..1653141 (-) Length 146 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S64_RS07870 (M5S64_07870) 1647723..1648745 + 1023 WP_003859324.1 HTH-type transcriptional regulator GalS -
M5S64_RS07875 (M5S64_07875) 1649041..1650039 + 999 WP_017383382.1 galactose/glucose ABC transporter substrate-binding protein MglB -
M5S64_RS07880 (M5S64_07880) 1650119..1651639 + 1521 WP_003859320.1 galactose/methyl galactoside ABC transporter ATP-binding protein MglA -
M5S64_RS07885 (M5S64_07885) 1651655..1652665 + 1011 WP_003859318.1 galactose/methyl galactoside ABC transporter permease MglC -
M5S64_RS07890 (M5S64_07890) 1652704..1653141 - 438 WP_045333654.1 helix-turn-helix transcriptional regulator Antitoxin
M5S64_RS07895 (M5S64_07895) 1653138..1654487 - 1350 WP_045333653.1 HipA domain-containing protein Toxin
M5S64_RS07900 (M5S64_07900) 1654622..1655332 - 711 WP_017383381.1 outer membrane permeability protein SanA -
M5S64_RS07905 (M5S64_07905) 1655460..1656344 - 885 WP_017693047.1 cytidine deaminase -
M5S64_RS07910 (M5S64_07910) 1656473..1657168 - 696 WP_015572322.1 CidB/LrgB family autolysis modulator -
M5S64_RS07915 (M5S64_07915) 1657165..1657560 - 396 WP_032671768.1 CidA/LrgA family protein -
M5S64_RS07920 (M5S64_07920) 1657729..1658664 + 936 WP_045340318.1 tRNA dihydrouridine(16) synthase DusC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-406)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 450 a.a.        Molecular weight: 51197.84 Da        Isoelectric Point: 4.6562

>T255634 WP_045333653.1 NZ_CP103577:c1654487-1653138 [Enterobacter hormaechei]
METLTVQAYLNETWTDIALIKYPGSEKNDWNTTQLDYLTEYAINFLDYDDFHAVSVNHPVSLFFDDHGQPGWLRFIDDII
PAGASRRYWINALDISELPVGQQNFLLLKFGTMSPVGNLRIKESVPEWNKFASTKTFTVADVIDRAADFLDYAQERGAAA
GGATGAGGEAPKLLLRCSETDAIWIDTWQNEPDNRDRYYLVKYPRGNRTEVDCNILRAEFHYYHELNAMGFSTIPVETMR
LEEGSHYPSLWLPRFDIVRNEQDQLVRLGMESVYSLLQKAPGTLLDHETTLRTLINKITSSHMVQQQGYHFDIPGFVTEW
VRRDLLNIIFGNSDNHGRNTAFVKAENQIMLSPVYDFAPMKADPEGIPRTLKWSLSCESGGDYNFNTIAQTLAEWIPPTT
LLDALHETAVQLIDLPERLAARGVPEQIMEMPAMGFRYIPDKLSRWGLL

Download         Length: 1350 bp

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 16171.61 Da        Isoelectric Point: 10.5154

>AT255634 WP_045333654.1 NZ_CP103577:c1653141-1652704 [Enterobacter hormaechei]
MKTPNEAESELLQTLAQVRSVNKKRHHDEAEDPDKPSVVKRQRVTQGLTRISTLDRQAVLHAAIRDILLGKITQGEALKR
LRVEVLGLKQDEYAKLVSVSRKTLSDVENNRGNYSADVINKIFKPFGLQTGLVPVSKSLIASLFS

Download         Length: 438 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G5A822

Antitoxin

Source ID Structure
AlphaFold DB A0A2G5A843

References