Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 299595..300191 Replicon chromosome
Accession NZ_CP103577
Organism Enterobacter hormaechei strain 4285

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag M5S64_RS01435 Protein ID WP_023295756.1
Coordinates 299889..300191 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A927HL08
Locus tag M5S64_RS01430 Protein ID WP_023295755.1
Coordinates 299595..299882 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S64_RS01425 (M5S64_01425) 297967..299598 + 1632 WP_003860350.1 Na/Pi cotransporter family protein -
M5S64_RS01430 (M5S64_01430) 299595..299882 - 288 WP_023295755.1 putative addiction module antidote protein Antitoxin
M5S64_RS01435 (M5S64_01435) 299889..300191 - 303 WP_023295756.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5S64_RS01440 (M5S64_01440) 300389..301261 + 873 WP_003860347.1 23S rRNA pseudouridine(2604) synthase RluF -
M5S64_RS01445 (M5S64_01445) 301262..301534 - 273 WP_017382612.1 DUF3811 domain-containing protein -
M5S64_RS01450 (M5S64_01450) 301585..302529 - 945 WP_015570166.1 ketopantoate/pantoate/pantothenate transporter PanS -
M5S64_RS01455 (M5S64_01455) 302623..303972 - 1350 WP_045340537.1 lysine-sensitive aspartokinase 3 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-93)

Antitoxin

Uncharacterized protein HI1420

(3-90)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11441.24 Da        Isoelectric Point: 10.1042

>T255631 WP_023295756.1 NZ_CP103577:c300191-299889 [Enterobacter hormaechei]
MKEIVQTESFRRWEQNLKDRRAKTIIASRLFRLANGLAGDIRPVGEGISELRIHFGPGYRIYFKDQGNCIIVLLCGGDKS
SQARDILMAKMLSNVSQWQE

Download         Length: 303 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10101.59 Da        Isoelectric Point: 5.7807

>AT255631 WP_023295755.1 NZ_CP103577:c299882-299595 [Enterobacter hormaechei]
MHKLTPYDPANALLDDEEIAVFMADALETGDSAYIAKALGVIARAKGMSTISQQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGLGLTIKPSGD

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References